血管因素在阿尔茨海默病中的作用

The role of vascular factors in Alzheimer's disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种神经退行性疾病,其发病机制尚未完全明确。近年来的研究发现,血管因素在AD的发生发展占重要的作用。一些脑血管疾病的危险因素如易感基因、脂代谢紊乱、动脉粥样硬化、高血压、糖尿病和高胱氨酸血症等与AD的关系密切。血管损伤因素诱导痴呆的发生,同时伴有AD样的病理改变。这使"血管假说"的重提具有更深远的意义,从多个视角去探讨其本质,为AD的认识、防治及治疗提供新的研究方向。

Alzheimer＇s disease is a neurodegenerative disease,in which the pathogenesis has not yet fully understood.In recent years,vascular factors play an important role in the pathogenesis of AD.Risk factors of cerebrovascular disease,such as susceptibility gene,lipid metabolism disorder,artherosclerosis,hypertension,diabetes and hyperhomocysteinemia are related to AD.The factors of vascular lesions induced dementia,generally accelerating the progression of AD.These results suggested that the vascular hypothesis have a more profound meaning,its essence is discussed from different perspectives,and it provides a new direction for the prevention and treatment of AD.