摘要
目的探讨瑞舒伐他汀对颈动脉硬化患者血脂水平及颈动脉内-中膜厚度（IMT）及斑块积分的作用。方法76例经颈动脉超声证实有颈动脉斑块患者，给予瑞舒伐他汀10mg／d，观察治疗前、治疗后6个月血脂水平及颈动脉IMT、斑块积分的变化。结果治疗6个月后，血清TC、LDL—C、TG均低于治疗前[分另0为（4．4±0．7）mmol／L比（6．3±0．8）mmol／L，（2．4±0．3）mmol／L比（4．4±0．4）mmol／L，（1．8±0．3）mmol／L比（2．8±0．5）mmol／L]，HDL—C高于治疗前[（1．21±0．27）mmol／L比（0．86±0．31）mmol／L]，差异均有统计学意义（均P〈0．05）。治疗6个月后IMT和斑块积分均小于治疗前[（1．24±0．27）mm比（1．77±0．32）mm，（3．3±0．3）分比（5．0±0．4）分，差异均有统计学意义（均P〈0．05）。结论瑞舒伐他汀可以明显降低颈动脉硬化患者TC、LDL—C、TG水平，升高HDL-C水平，降低颈动脉斑块厚度及斑块积分。
Objective To study the effects of rosuvastatin on serum lipid level and carotid arterial intima- media thickness （IMT） and carotid plaque score in patients with carotid atherosclerosis. Methods Seventy-six pa- tients diagnosed by color doppler ultrasound with carotid artery plaque were given rosuvastatin 10 mg/d. Lipid levels and IMT were measured and carotid plaque score was calculated before and 6 months after the treatment. Results Six months after the treatment, serum TC level was reduced significantly from （6.3 ± 0.8 ） mmol/L to （4.4 ± 0.7） mmol/L. TG level was reduced significantly from （2.8 ± 0.5 ） mmol/L to （ 1.8 ±0.3 ） mmol/L. LDL- C level was reduced significantly from （4.4± 0.4） mmol/L to （2.4 ±0.3 ） mmol/L. HDL-C level was elevated significantly from （0.86 ±0.31 ） mmol/L to （ 1.21 ± 0.27 ） mmol/L （ P 〈 0.05 ）. Six months later, IMT reduced significantly from （ 1.77 ±0, 32） scores to （ 1.24 ±0.27） scores, and carotid plaque score reduced significantly from （5.0 ±0.4） scores to （3.3 ±0.3 ） scores （ P 〈 0.05 ）. Conclusions ①Rosuvastatin can significantly reduce serum TC, LDL-C, TG levels and elevate HDL-C level in patients with carotid atherosclerosis. ②Rosuvastatin can significantly reduce IMT and carotid plaque score, which can stabilize and regress plaque in carotid artery.
出处
《中国医药》
2013年第4期436-437,共2页
China Medicine
