环磷腺苷葡胺治疗缓慢性心律失常临床观察

Cfinlcal observation of effect of meglumine adenosine cyclophosphate on slow arrhythmia

目的观察环磷腺苷葡胺（MAC）治疗器质性心脏病缓慢性心力律失常的临床疗效。方法在常规治疗的基础上，将46例缓慢性心律失常患者完全随机分为MAC组和对照组，各23例。对照组给予扩张血管、利尿、降低血压、改善心功能等常规治疗；MAC组在对照组治疗的基础上，加用MAC120mg于250ml葡萄糖液体内静脉滴注，每日1次。2组均以14d为1个疗程。观察2组治疗前后患者平均心率和临床症状改善情况，并评价疗效。结果MAC组治疗后Holter心电图心率明显高于治疗前和对照组治疗后[（60±5）次／min比（52±3）次／min、（54±4）次／min]，差异均有统计学意义（均P〈0．05）；MAC组治疗后临床总有效率明显高于对照组[87．0％（20／23）比78．3％（18／23）]，差异有统计学意义（P〈0．05）。结论MAC能增加器质性心脏病缓慢性心律失常患者的心率，可提高临床有效率，改善临床症状。

Objective To observe the clinical effects of meglumine adenosine cyclophosphate （MAC） on slow arrhythmia heart disease. Methods All 46 patients with slow arrhythmia were randomly divided into the treatment group and the control group with 23 patients each. The patients in the control group underwent the basis of conventional treatment. In addition of the conventional therapy, the treatment group was additionally treated with 120 mg MAC in 250 ml liquid drops daily. 14 days was a course of treatment. ECG and symptoms after the treatment were observed and compared. Results The heart rate after operation in treatment group was higher than that before treatment and that postoperation of control group [ （60 ± 5 ） times per min vs （52 ± 3 ）, （ 54 ± 4） times per min ], and there was significant difference （ all P 〈 0.05 ）. The total effective rate in the treatment group was higher than that in control group [ 87.0% （20/23） vs 78.3 % （ 18/23）, P 〈 0.05 ]. Conclusions MAC can not only increase the heart rate of patient with organic heart disease and decrease the slow arrhythmia. It also improves the clinical outcome and ameliorate the symptoms.