口服三金片联合左氧氟沙星治疗尿路感染临床疗效观察

Clinical efficacy of urinary tract infectious treated by oral Sanjin tablets joint levofloxacin

目的观察口服左氧氟沙星合用三金片治疗尿路感染的临床效果。方法按就诊顺序将86例尿路感染患者随机分为观察组和对照组，口服左氧氟沙星缓释片，0．2g／次，2次／d，同时服用三金片17．5g／次，3次／d；对照组：口服左氧氟沙星缓释片，0．2g／次，2次／d，同时服用八正合剂20ml，3次／d；疗程均为7～10d。对其疗效进行评价。比较2组患者的临床疗效、细菌清除率及尿频、尿急、尿痛、小腹坠胀消失时间。结果观察组临床有效率明显优于对照组[81．0％（34／42）比61．4％（27／44），χ^2=3．99，P〉0．05]，观察组治疗前中段尿细菌培养出致病菌36株，对照组培养出30株，观察组治疗后细菌清除率亦优于对照组[80．6％（29／36）比70．3％（26／30），P〉0．05]，不良反应发生率低于对照组，但差异无统计学意义[9．5％（4／42）比11．4％（5／44）]。结论口服左氧氟沙星合用三金片治疗尿路感染比口服左氧氟沙星合用八正合剂治疗尿路感染效果较好。

Objective To observe the clinical effect of oral levofloxacin in combination with Sanjin tablets and oral levofloxacin in combination with Bazheng mixture on urinary tract infection （UTI）. Methods Eighty-six cases of UTI were randomly divided into observation group （42 cases） and control group （44 cases）. Observation group were given oral Levofloxacin in combination with Sanjin tablets observed group and control group were given oral levofloxacin in combination with bazheng mixture. The clinical efficacy, the rate of bacterial clearance and urinary frequency, urgency, dysuria, abdominal bulge disappear time of both group were compared. Results The effective rates in observation group was higher than that in the control group [ 81.0% （34/42） vs 61.4% （27/44, χ^22 = 3.99, P 〉 0.05 ] ; the germ-clearance rates was also better than that in control group [ 80.6% （29/36） vs 70.3% （26/30）, P 〉0.05] ; the adverse drug reaction was lower than that in control group [9.5% （4/42 vs 11.4% （5/ 40） ]. Conclusion Treating combined levofloxacin and Sanjin tablets is better than combined levofloxacin and bazheng mixture to treat UTI.