喹硫平治疗前后双相Ⅱ型抑郁发作患者多导睡眠脑电图对照研究

Control study of quetiaphine in polysomnography applied to patients with paralepsy type Ⅱ bipolar mood disorder

目的探讨喹硫平片治疗前后双相Ⅱ型抑郁发作患者多导睡眠脑电图的特点。方法选取从未接受过药物治疗的双相Ⅱ型抑郁发作患者34例，观察治疗前、治疗1个月后的睡眠脑电图情况，并与34名正常人（对照组）进行对照。结果①睡眠进程：研究组治疗前总睡眠时间、睡眠效率低于对照组（P〈0．01），睡眠潜伏期、醒起时间、清醒次数、清醒时间、〉5min清醒次数、觉睡比高于对照组（P〈0．05或P〈0．01）。治疗后，研究组总睡眠时间、睡眠效率分别为（429±29）min、（99．5±0．4）％，高于治疗前（P〈0．01）；睡眠潜伏期、醒起时间、清醒次数、清醒时间、〉5min清醒次数、觉睡比分别为（18±4）min、（6±3）min、（0．9±0．5）次、（2．3±2．2）min、（0．0±0．0）次、（0．5±0．4）％，均低于治疗前（P〈0．05或P〈0．01）。②睡眠结构：研究组治疗前后快动眼睡眠所占百分比均高于对照组，非快动眼睡眠3期所占百分比均低于对照组，差异均有统计学意义（P〈0．05或P〈0．01）。③快动眼睡眠指标：研究组治疗前快动眼睡眠活跃度、快动眼睡眠强度、快动眼睡眠密度均高于对照组（P〈0．05或P〈0．01），快动眼睡眠时间、快动眼睡眠潜伏期低于对照组（P〈0．01）；研究组治疗后，快动眼睡眠时间高于治疗前，快动眼睡眠潜伏期低于对照组，快动眼睡眠活跃度、强度、密度低于治疗前但均高于对照组，差异均有统计学意义（P〈0．01）。结论双相Ⅱ型抑郁发作患者睡眠脑电图有普遍明显异常表现，经治疗后指标明显改善。但快动眼睡眠百分比、非快动眼睡眠3期所占百分比及快动眼睡眠潜伏期、睡眠活跃度、睡眠强度、睡眠密度治疗后仍然明显异常。

Objective To observe sleep electroencephalogram characteristic of paralepsy type Ⅱ bipolar mood disorder patients treated with quetiapine famarate tablets. Methods All 34 patients who did never treated with any medicines were selected, and sleep encephalograms difference before and after treatment for one month was observed, and in comparison with 34 normal control group. Results ①Sleep progress ： total sleep time, sleep efficiency of study group before treatment was lower than those of control group （ P 〈 0.01 ）. Sleep latency period, wake up time, awaken number, 〉 5 min awaken time, awaken number and awaken time against sleep time were higher than those of control group （ P 〈 0.05 or P 〈 0.01 ）. Total sleep time, sleep efficiency after treatment in study group were （ 429 ± 29 ） min and （99.5 ±0.4 ） %, which were higher than those before treatment （ P 〈 0.01 ） ; sleep latency period, wake-up time, awaken number, 〉 5 min awaken time, awaken number and awaken time against sleep time were accordingly （18 ±4）min, （6 ±3）min, （0.9 ±0.5）times, （2.3 ±2.2）min, （0.0 ±0.0）times and（0.5 ±0.4） %, which were lower than the ones before treatment（ P 〈 0.05 or P 〈 0.01 ）. ②Sleep structure： rapid eye movement sleep of study group before and after treatment took higher percentage than control group, and non rapid eye-movement sleep Ⅲ stage took lower percentage than control group, difference had statistics influence （ P 〈 0.05 or P 〈 0.01 ） ;③ Rapid eye-movement sleep index： rapid eye movement sleep activeness, rapid eye movement sleep intensity, rapid eye movement sleep density of study group before treatment were higher than control group （ P 〈 0. 05 or P 〈 0. 01 ）. Rapid eye movement sleep, rapid eye movement sleep latency period were lower than control group （P 〈0.01） ;In study group, rapid eye movement sleep after treatment was higher than the one before treatment. Rapid eye movement sleep latency period was lower than control group. Rapid eye movement sleep activeness, rapid eye movement sleep intensity, rapid eye movement density were lower than the one before treatment, but averagely higher than control group. Difference had statistics influence （P 〈 0.01 ）. Conclusions Comments sleep encephalogram of paralepsy type Ⅱ bipolar mood disorder patients shows generally obvious unusual, after treatment indexes get much improved. However rapid eye movement sleep percentage, non rapid eye movement sleep m stage percentage, rapid eye movement sleep latency period, rapid eye movement sleep activeness, rapid eye movement sleep intensity, rapid eye movement sleep density indexes are remain abnormal.