普瑞巴林联合伐昔洛韦治疗带状疱疹的临床研究

The clinical research of the treatment of herpes zoster by pregabalin combination with antiviral drugs

目的探讨普瑞巴林治疗带状疱疹神经疼痛的疗效。方法将32例带状疱疹患者完全随机分为观察组和对照组，各16例。对照组患者静脉滴注伐昔洛韦150mg／次，2次／d，研究组在对照组治疗的基础上加用普瑞巴林150mg／次，2次／d，口服。比较2组患者治疗前及治疗后3d、1、2、4及8周时疼痛积分和临床疗效。结果治疗前和治疗3d后2组疼痛积分差异无统计学意义，治疗后1、2、4、8周研究组的疼痛积分明显小于对照组[分别为（2．3±1．3）分比（3．8±2．0）分，（2．0±0．9）分比（3．5±1．8）分，（2．0±0．6）分比（3．5±1．1）分，（2．0±0．5）分比（3．5±0．8）分，差异均有统计学意义（P〈0．05），研究组治愈11例，显效3例，好转1例，无效1例；对照组治愈7例，显效3例，好转4例，无效2例。结论联合治疗带状疱疹可使抗病毒药物治疗带状疱疹的疗效增加、疼痛程度减轻，可以明显降低后遗神经痛发生率。

Objective To investigate the efficacy of pregabalin in the treatment of herpes zoster nerve pain. Methods Thirty-two patients with herpes zoster were randomly divided into observation group and the control group, each 16 cases. The control group were given intravenous infusion valaciclovir 150 mg/time, 2 times/d, observation group were treated with pregabalin 150 mg/time, 2 times/d, orally. Before treatment, 3d, 1w, 2w, 4w, 8w after treatment, the pain scores and clinical efficacy comparison of both group were compared. Results There were no significant difference in pain scores before treatment and after 3 d, 1, 2, 4, and 8 weeks after treatment, the pain scores of the observation group was significantly less than the control group [ （2.3 ± 1.3 ） scores vs （3.8＋2.0） scores, （2.0±0.9） scores vs （3.5 ±1.8） scores, （2.0±0.6） scores vs （3.5±1.1） scores, （2. 0 ±0.5） scores vs （3.5 ±0.8） scores], the differences are had statistically significant（P 〈0. 05）. In observation group, 11 cases were cured, 3 cases were markedly, 1 case was improved, 1 case was ineffective;In control group 7 cases were cured, 3 cases were markedly, 4 cases was improved, 2 cases was ineffective. Conclusions Combination valaciclovir and pregabalin treatment of herpes zoste can increase the efficacy of antiviral treatment of herpes zoster and reduce the level of pain, can significantly reduce the incidence of postherpetic neuralgia.