喜炎平注射液联合利巴韦林喷剂治疗疱疹性咽峡炎疗效观察

Analysis of effect of Xiyanping injection combined with ribavirin spray in the treatment of herpangina

目的探讨喜炎平注射液联合利巴韦林喷剂治疗疱疹性咽峡炎的疗效。方法将2009年11月至2012年4月住院确诊疱疹性咽峡炎的患儿246例完全随机分为观察组（126例）和对照组（120例）。对照组给予利巴韦林10～15mg／（kg·d）静脉滴注；观察组给予喜炎平注射液0．1—0．2ml／（kg·d）静脉滴注，加用利巴韦林喷剂喷口腔。疗程5d。2组均给予退热等对症处理，合并细菌感染者加用口服头孢克肟颗粒2～3mg／（kg·d）。观察2组患儿退热时间和咽痛、流涎消失时间及疱疹消退时间，并采用2组样本均数比较的t检验进行分析比较。结果观察组总有效率[96．8％（122／126）]明显高于对照组[89．2％（107／120）]，差异具有统计学意义（P〈0．05）。观察组与对照组退热时间和咽痛、流涎消失时间及疱疹消退时间比较，差异均有统计学意义[（2．3±0．8）d比（4．0±1．0）d，（3．2±1．4）d比（4．4±1．3）d，（3．2±0．7）d比（5．0±0．6）d，均P〈0．05]。结论喜炎平注射液联合利巴韦林喷剂治疗疱疹性咽峡炎可缩短病程，提高总有效率，临床疗效显著。

Objective To investigate the clinical efficacy of Xiyanping injection combined with ribavirin spray on herpangina. Methods Two hundred and forty-six children with herpangina admitted to Zhengzhou second people＇s hospital from Nov. 2009 to Apr. 2012 were reviewed. All 246 eases of children with herpangina were randomly divided into two groups. The patients in control group were treated with ribavirin [ 10-15 mg/（ kg · d） ] by intravenous drip, and the patients in observation groups were treated with xiyanping injection [ 0. 1-0.2 ml/ （ kg · d） ] by intravenous drip and ribavirin spray by eonspergering into mouth cavity. All patients received pyretolysis treatment. The patients with bacterial infections were given antibiotics. The time of pyretolysis, extinction time of sore throat, salivation and herpes were observed for 5 days. Results The total effective rate in observation group [96.8% （122/126） ] was significantly higher than that in the control group[89.2% （107/120） ] （P 〈0.05）. The time of pyretolysis, pharyngalgia and salivate disappear, herpes extinction in observation group were shorter than those in control group [ （2.3 ±0.8）d vs（4.0 ± 1.0）d, （3.2 ±1.4）d vs （4.4 ±1.3）d, （3.2 ±0.7）d vs （5.0 ±0.6） d, all P 〈 0.05 ]. Conclusions Xiyanping injection combined with ribavirin spray on herpangina can shorten the pathogenesis, raise recovery rate, and has a significant effect on herpangina.