摘要
由人类免疫缺陷病毒-1(HIV-1)感染引发的艾滋病始终威胁着人类的健康和生命。根据联合国艾滋病规划署2012年最新报道,2011年全球新发HIV感染者约为250万,170万人死亡,截至2011年末约有3 400万人忍受着艾滋病的折磨。非洲、撒哈拉一带仍然是全球感染最严重的地区。
MicroRNA (miRNA) is one of the multifunctional small RNAs that have been extensively investi- gated in recent years. MiRNA-mediated RNA interference regulates cell proliferation, differentiation, devel- opment and plays a critical role in many infectious diseases such as acquired immunodeficiency syndrome (AIDS). MiRNA inhibits HIV-1 replication by targeting the genome RNA or interacting with protein-coding mRNA but it also facilitates HIV-1 infection and AIDS progress by promoting T cell proliferation that is medi- ated by activating innate immune system and producing cytokines. Meanwhile, miRNA can also affect HIV-1 replication by interacting with viral accessory proteins and host cellular factors. Some miRNAs are involved in HIV-1 latency. Furthermore, miRNA expression profile could be fluctuated with HIV-1 infection which can be used as a diagnostic indicator in the near future.
出处
《中国病毒病杂志》
CAS
2013年第2期155-159,共5页
Chinese Journal of Viral Diseases
基金
国家自然科学基金青年科学基金项目(30901257)