医院2011年铜绿假单胞菌分布与耐药性分析

Distribution and drug resistance of Pseudomonas aeruginosaisolated in 2011

目的了解医院2011年铜绿假单胞菌分布及其对常用抗菌药物的耐药性,为临床合理使用抗菌药物提供可靠依据。方法对2011年1-12月各临床标本中分离的铜绿假单胞菌,进行抗菌药物药敏试验,依据2010年CLSI标准判读,并进行回顾性分析。结果分离出的462株铜绿假单胞菌中痰液、下呼吸道分泌物检出最高,检出率为72.1%,主要见于呼吸系统疾病;铜绿假单胞菌对13种抗菌药物均产生了不同的耐药性,对米诺环素的耐药率高达74.7%,对加酶抑制剂的复合类抗菌药物比单种抗菌药物的敏感性好;对亚胺培南和美罗培南的耐药率有显著增高,分别为41.3%和38.5%,对头孢菌素类的耐药率<20.0%。结论医院铜绿假单胞菌对常用抗菌药物产生了高耐药性,应加强医院感染的检测与控制。

OBJECTIVE To investigate the distribution and the drug resistance of Pseudomonas aeruginosa isolated in 2011,so as to provide basis for rational use of antibiotics.METHODS The drug susceptibility testing was performed for the P.aeruginosa strains isolated from various clinical specimens between Jan and Dec 2011.The result was determined according to the CLSI,2010 edition and was analyzed retrospectively.RESULTS Of totally 462 strains of P.aeruginosa isolated,most were isolated from the sputum and the lower respiratory tract secretions,the detection rate was 72.1%.The isolates were common in the patients with respiratory system disease.P.aeruginosa strains varied in the drug resistance to 13 antibiotics,and the drug resistance rate to minocycline was 74.7%,and the strains were more sensitive to the enzyme inhibitor complex class of antibiotics than to single antibiotics.The resistance rates to imipenem and meropenem were 41.3% and 38.5%,with the trend increasing notably.The resistance rate to cephalosporins was less than 20.0%.CONCLUSION The P.aeruginosa strains isolated from the hospital show high resistance to common antibiotics.It is necessary to strengthen the detection and control of nosocomial infections.