女性生殖道解脲脲支原体及人支原体耐药性变迁分析

Change of drug resistance of Ureaplasma urealyticumand Mycoplasma hominisin female reproductive tract

目的分析杭州地区女性生殖道解脲脲支原体(Uu)和人支原体(Mh)耐药性变迁。方法对28 397例女性患者生殖道标本进行支原体属检测,对Uu和Mh进行体外药物敏感试验。结果 2009-2011年支原体属阳性的标本为15 998例,阳性率为56.34%;其中单纯Uu感染占75.94%,单纯Mh感染占2.19%,Uu和Mh混合感染占21.87%;Uu对氧氟沙星的耐药率2009年为46.07%、2010年为49.46%、2011年为53.22%,2009年均低于2010年和2011年,差异有统计学意义(P<0.05),3年均有上升趋势;Uu对环丙沙星的耐药率2009、2011、2010年分别为72.97%、73.93%、75.28%。结论杭州地区Uu对喹诺酮类药物的耐药率有明显增加趋势,临床治疗过程中应减少经验性用药,加强支原体属的培养及药物敏感性试验,减少耐药菌株的产生。

OBJECTIVE To investigate the change of drug resistance of Ureaplasma urealytium（Uu） and Mycoplasma hominis（Mh） isolated from the reproductive tracts of the female in Hangzhou.METHODS The reproductive tract specimens of 28 397 female patients were cultured for Mycoplasma,and the in vitro antibiotics susceptibility testing of the Uu and Mh was performed.RESULTS There were 15 998 cases of patients tested positive with Mycoplasma from 2009 to 2011,the positive rate was 56.33%,among which the patients with the single Uu infection accounted for 75.94%,the patients with single Mh infection accounted for 2.19%,and the patients with mixed Uu and Mh infections accounted for 21.87%.The drug resistance rate of Uu to ofloxacin was 46.07% in 2009,49.46% in 2010,and 53.22% in 2011,the difference was statistically significant（P0.05）,and the drug resistance rate kept an upward tendency during the three years（P0.05）.The drug resistance rate of Uu to ciprofloxacin was 72.97% in 2009,73.93% in 2010,and 75.28% in 2011（P0.05）.CONCLUSION The drug resistance rate of Uu to quinolones is significantly increased in Hangzhou.It is necessary to reduce the empirical use of antibiotics during the clinical treatment and strengthen culture of Mycoplasma and the drug susceptibility testing so as to reduce the drug resistant strains.