黄芪注射液在小儿肠梗阻术后肠功能恢复中的作用观察

Effect of Huangqi injection on postoperative intestinal function recovery in children with mechanicalileus

目的探讨黄芪注射液在小儿机械性肠梗阻术后肠功能恢复中的作用。方法将本院诊断明确并手术治疗的96例肠梗阻患儿按随机原则分为黄芪组（50例）和对照组（46例）。两组患儿术后均常规输液、抗炎治疗，黄芪组在常规治疗基础上术后连续3d静脉滴注黄芪注射液0．5ml·kg^-1·d^-1。（加入10％葡萄糖注射液100-250m1）。治疗前和治疗后48h抽血，测定两组血清二胺氧化酶（DAO）、超氧化物歧化酶（SOD）及单胺氧化酶（MAO）活性，并观察两组患儿胃肠功能恢复时间。结果两组治疗前DAO、SOD、MAO活性比较差异均无统计学意义（均P〉0．05）；治疗后，黄芪组DAO、SOD活性较治疗前明显增高，MAO活性较治疗前明显降低，且以黄芪组上述指标的改善程度较对照组显著[DAO（kU／L）：6．99±3．02比4．59±2．19，MAO（kU／L）：16．92±13．37比61．19±22．54，SOD（kU／L）：140．77±8．22比129．49±14．23，均P〈0．01]；黄芪组胃肠功能恢复时间较对照组明显缩短（h：23．92±13．51比35．57±15．14，P〈0．01）。结论黄芪注射液能明显缩短小儿肠梗阻术后胃肠功能恢复时间，对小儿肠梗阻肠缺血／再灌注（I／R）损伤有保护作用。

Objective To explore the effect of Huangqi injection on postoperative intestinal function recovery in children with mechanical ileus. Methods Ninety-six patients with definite diagnosis of mechanical ileus and surgical intervention were randomly divided into astragalus group （50 cases） and control group （46 cases） . In both groups, the routine treatments of intravenous injection of fluid and anti-inflammatory drugs were given. In astragalus group, astragalus injection （0.5 ml·kg^-1·d^-1） in 10% glucose 100-250 ml was additionally administered via intravenous drip for consecutive 3 days. Before treatment and 48 hours after treatment, the activities of serum diamine oxidase （DAO）, superoxide dismutase （SOD） and monoamine oxidase （MAO） were detected, and the intestinal functional recovery time was observed in the two groups. Results Before treatment, the serum activities of DAO, SOD and MAO in astragalus group had no statistical significant differences from those in the control group （all P〉0.05） ; after treatment, the DAO and SOD activities were obviously increased, while the MAO activity was markedly decreased in the astragalus group, showing remarkable statistical differences from those in the control group DAO （kU/L） ： 6.99±3.02 vs. 4.59±2.19, MAO （kU/L） ： 16.92± 13.37 vs. 61.19±22.54, SOD （kU/L） ： 140.77± 8.22 vs. 129.49 ± 14.23, all P〈 0.01 ]. The time of intestinal function recovery in the astragalus group was significantly shorter than that in the control group （hours ： 23.92± 13.51 vs. 35.57 ± 15.14, P〈0.01） . Conclusion Huangqi injection can significantly shorten the time for recovery of intestinal function after operation and plays an important role in protecting intestinal ischemia/reperfusion （I/R） injury in post-operative children with mechanical ileus.