羊栖菜多糖对小鼠抗疲劳作用的研究

Study on the effect of polysaccharide from Hizikia fusiformis of anti-fatigue of mice

研究羊栖菜多糖对小鼠的抗疲劳作用,对于开发利用羊栖菜资源具有重要意义。通过对小鼠灌胃不同剂量的羊栖菜多糖(50、150mg/mL·d),经15d后测定小鼠体重、负重游泳力竭时间、超氧化物歧化酶(SOD)、丙二醛(MDA)、肝糖原、肌乳酸及血清尿素的含量,研究羊栖菜多糖抗疲劳作用机理。结果表明,羊栖菜多糖对小鼠体重增长无明显影响(p>0.05),但能明显延长小鼠负重游泳时间(p<0.01),增强小鼠血清SOD活性(p<0.01),提高肝糖原含量(p<0.01),降低血清MDA(p<0.05)、肌乳酸(p<0.01、0.05)及血清尿素(p<0.01)的含量。说明羊栖菜多糖具有抗疲劳的作用。

The aim of this study was to develop whether the polysaccharides extracted from H.fusiformis have the anti-fatigue effect on mice. It was important for the further development of H. fusiformis. The weight, loading swimming time, the activities of blood SOD, the content of blood MDA, liver glycogen, muscle lactic acid, the content of blood urea nitrogen were measured after 15 days through being given different doses （50, 150mg/mL·d） of the polysaccharides to mice. The result showed there was no significant difference on the body weights between control and polysaccharides fed mice （p〉0.05）. However,the loading swim time （p〈0.01）, the activity of SQD （p〈0.01） and the concentration of liver glycogen （p〈0.01） were enhanced,while the concentration of MDA（p〈0.01）, muscle lactic acid （p〈0.01,0.05） ,and urea in blood （p〈0.01） were decreased. In conclusion,the polysaccharides extracted from H. fusiformis do had anti-fatigue effect on mice.