中医药对注意力缺陷多动障碍的动物实验规范化探讨

Considerations regarding animal research of traditional Chinese medicine on attention deficit hyperactivity disorder

注意力缺陷多动障碍(ADHD)是儿童时期常见的行为障碍性疾病,近年来,中医药对ADHD的动物实验研究逐渐得到发展,但在研究设计、动物福利等方面仍存在不足,直接影响了中医药研究成果的真实性与认可度。该研究结合中医药本身的特点,对其中存在的问题进行探讨分析,希望能有效推动中医药动物实验规范化,充分发挥实验动物科学在ADHD中医药研究中的作用。

Attention-deficit/hyperactivity disorder （ADHD） is a common developmental neuropsyehiatric disorder. Althougt ADHD can often be treated with stimulant class medications to alleviate symptoms, such treatments may cause undesirable side effects. Recently, Traditional Chinese medicine （TCM） has been gaining interest with treatment potential for ADHD and the lack of the stimulant-associated undesirable side effects. Animal models are useful for study the efficacy and mechanisms of TCM treatment for ADHD, however, previous studies of TCM on ADHD animal models, in general, have not considered appropriate experiemental designs. There were many concerns regarding the choice and source of the model and control animals, drug administration methods, behavioral and biochemical testing criteria, humane use of animals, and statistical power, etc. In this review, we discuss these issues present in the previous literature of animal research, and propose guidelines for future studies in particular consideration with the unique characteristic of Chinese medicine itself.