重症手足口病146例临床分析

Clinical analysis of 146 children with severe hand-foot-mouth diseases

目的探讨重症手足口病的发病规律和临床特征及有效的治疗方法。方法分析146例重症手足1：7病住院患儿的临床资料，总结重症手足口病的临床特点及发病规律。结果146例重症手足口病惠儿均以皮疹、发热起病，所有病例热程均〉36h，热程在96h以内者142例，在120h以内者4例；体温37．8～40．5℃。早期的临床表现有惊跳、肢体抖动、头痛、便秘等。所有患儿均接受甘露醇、静脉用丙种球蛋白、糖皮质激素等治疗。结论发热是重症手足口病发病的重要危险因素，重症手足口病的发生、发展及转归有其一定的规律。

Objective To investigate the occurrence rule, clinical characteristic and effective therapy of hand-foot-mouth disease （HFMD）. Methods The clinical data of 146 hospitalized children with severe HFMD were analyzed, and the clinical characteristic and occurrence rule of severe HFMD was summarized. Results All of the 146 children with severe HFMD had onset of rash and fever and their duration of fever were more than 36 hours. Duration of fever in 146 cases were less than 96 hours and 4 cases were less than 120 hours. The range of all body temperture were from 37.8 ~C to 40.5 ~C. The early clinical manifestaions were startle, limbs shaking, headache and constipation. All of the chil- dren received therapy of mannitol, intravenous gamma globulin and glucocorticoid. Conclusions The fever is an important risk factor for severe HFMD, and the occurrence, development and prognosis of severe hand-foot-mouth disese have a certain regularity.