癌复灵对荷瘤小鼠免疫功能和术后体力恢复的影响

Influence of Aifuling compound on immune function and postoperative physical recovery in tumor-bearing mice

目的:探讨中药复方癌复灵对荷瘤小鼠免疫功能和荷瘤术后体力恢复的影响。方法:通过测定荷瘤小鼠用环磷酰胺(CTX)化疗后血清溶血素含量与脾细胞分泌抗体功能,以及绵羊红细胞(SRBC)所致的荷瘤小鼠迟发型足垫肿胀试验,观察癌复灵对肿瘤机体免疫功能的影响;采用小鼠游泳试验评价癌复灵对荷瘤小鼠化疗后手术恢复期体力的影响。结果:癌复灵4g.kg-1灌胃能明显对抗CTX化疗所致的荷瘤小鼠IgM含量降低;显著增强荷瘤后化疗小鼠脾细胞分泌抗体的功能;明显对抗CTX对SRBC致荷瘤小鼠足垫肿胀的抑制作用;能延长化疗后手术恢复期小鼠的游泳时间,有效改善恢复期体力。结论:癌复灵具有增强肿瘤机体免疫功能和促进手术后体力恢复的作用。

OBJECTIVE To study the effect of traditional Chinese medicine compound Aifuling on immune function and postoperative physical recovery in tumor-bearing mice. METHODS By means of hemolysin content test in serum, spleen antibodysecreting cell function test, and the delayed footpad reaction to SRBC in carcinomatous mice after chemotherapy, the effects of traditional Chinese medicine compound Aifuling on immune function were explored in tumor-bearing mice. The mice swimming test was used to evaluate the effect of Aifuling on physical strength of recovery in carcinomatous mice after chemotherapy. RESULTS For carcinomatous mice after chemotherapy, Aifuling 4g.kg^-1 ig qd × 20 d could apparently against the IgM content decline caused by CTX, strengthen the spleen antibody-secreting cell function, against CTX inhibition to the delayed footpad reaction caused by SRBC, prolong the swimming time in mice. CONCLUSION The traditional Chinese medicine compound Aifuling can enhance the immune function and promote physical recovery in tumor-bearing mice.