离子液体催化合成柠檬酸植物甾烷醇酯的研究

Synthesis of citrate phytosterol esters in the presence of ionic liquid

研究了离子液体在柠檬酸植物甾烷醇酯合成中的应用。通过植物甾烷醇酯化率的对比,确定最佳反应条件为:离子液体[pmim][HSO4]用量为植物甾烷醇质量的7%,酸醇摩尔比3∶1,植物甾烷醇的浓度0.15 mmol/mL,带水剂为甲苯,反应温度110℃,反应时间5 h。在最佳条件下,经3次平行实验测得平均酯化率大于91%。离子液体[pmim][HSO4]在循环使用6次后仍有较高的催化活性。由质谱分析可知,合成的产物为柠檬酸植物甾烷醇酯。

The synthesis of citrate phytosterol esters in the presence of various ionic liquids was studied. The highest yield （ 〉 91% ） of citrate phytosterol esters was obtained under the optimal conditions： [ pmim] [ HSQ] dosage 7% （based on the phytostanol mass）, molar ratio of citric acid to phytostanol 3： 1, phytostanol concentration 0. 15 mmol/mL, toluene as water - entrainer, reaction temperature 110 ~C, reaction time 5 h. [ pmim ] [ HSO4 ] had highly catalytic activity after six operation runs. The product was confirmed to be citrate phytosterol esters by mass spectroscopy.