基于海藻酸钙-聚乙烯醇共混物的离子响应型泪道栓子的制备及性能

Preparation and Properties of an Ion-Sensitive Lacrimal Plug Based on Ca-Alginate-PVA

利用"溶液共混-挤出交联-冷冻干燥"法制备了基于海藻酸钙-聚乙烯醇(PVA)共混物的离子响应型泪道栓子,研究了PVA用量对共混材料体积膨胀率、吸水率及降解性能的影响。结果显示,在模拟泪液中,各共混材料的膨胀速率均与时间成线性关系,膨胀速率随着PVA用量的增加而逐渐降低,膨胀曲线斜率从66.53降至10以下。另外,随着PVA用量的增加,共混材料的吸水率以及降解过程中的质量保留率均先减少后增大,分别当PVA用量为20%时达到最小。

An ion-sensitive lacrimal plug based on Ca-alginate-PVA was prepared using ＂solution blendingexclusion and crossing-freeze drying＂ method. The effects of PVA content on volume expansion ratio, water absorption, and degradation of blends were discussed. The results indicate that a linear relationship between water absorption and time for all blends in the simulated tear fluid is observed, and the expansion curve slop decreases from 66.53 to less than 10 when PVA content increases from 0 % to 40 %. Furthermore, with the PVA content increasing from 0 % to 40 %, the water absorption rate and mass retention rate decrease first then slightly increase, reach the minimum when PVA content is 20 %.