微波辐射下合成DL-天冬氨酸的研究

Study on synthesis of DL-aspartic acid under microwave irradiation

在微波辐射下,以NH4Cl为催化剂,用顺丁烯二酸和氨水一步合成DL-天冬氨酸,通过正交实验和单因素实验,考察了微波功率、反应温度、催化剂用量、反应时间等因素的影响,得到最优的工艺条件为:n(顺丁烯二酸)∶n(氨水)∶n(氯化铵)=1∶3.4∶1.4,微波功率为80W,反应温度为160℃,反应时间为10min。这种方法具有操作简单,反应时间短,产品收率高等特点。

Under microwave irradiation, DL-aspartic acid was synthesized from malefic acid and ammonia water with ammonium chloride as catalyst agent. Effects of microwave power,reaction temperature, amount of catalyst agent, reaction time etc. on reaction were studied by a single factor tests and the orthogonal test. The optimal reaction conditions were：n（ malefic acid） ：n（ ammonia water） ：n （ ammonium chloride） = 1 ： 3.4 ： 1.4, with 80w microwave power, 160℃ reaction temperature, and 10-minute reaction time. This method provided several advantages such as easy operation, reaction time-saving and high yields.