摘要
利用GC-MS检测Mucor sp.转化肉桂酸的产物,对微生物Mucor sp.降解肉桂酸的途径进行了分析。β-苯乙醇首次作为微生物Mucor sp.转化肉桂酸生成苯乙酮的中间体在产物中被检测到。Mucor sp.降解肉桂酸的途径是:在肉桂酸的侧链双键上先发生环氧化反应得到3-苯基-2,3-环氧丙酸,环氧化合物经脱羧、还原开环得到中间体β-苯乙醇,β-苯乙醇经羟基转移和进一步催化氧化生成苯乙酮。
The metabolic pathway for the degradation of cinnamic acid with Mucor sp. was studied by analyzing metabolites using GC-MS. /3-Phenethyl alcohol, for the first time, was detected as an intermediate in transforming cinnamic acid to acetophenone by Mucor sp.. The metabolic pathway of cinnamie acid was supposed: epoxidation reaction occurred on the double bond of cinnamic acid side chain to generate ethyl 2,3-epoxy-β-phenylpropionic acid, the epoxide was converted to β-phenethyl alcohol via decarboxylation and ring-opening reaction, and, lastly, acetophenone was produced from fl- phenethyl alcohol via hydroxyl migration and oxidation reaction.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2013年第4期439-441,446,共4页
Fine Chemicals
基金
广西壮族自治区科技厅科学研究项目(桂科攻1099061-2)~~
关键词
MUCOR
SP
微生物转化
肉桂酸
Β-苯乙醇
途径分析
苯乙酮
中间体
生物工程
Mucor sp.
microbial transformation
cinnamic acid
^-phenethyl alcohol
pathwaysanalysis
acetophenone
intermediates
biological engineering