摘要
以4-氯苯乙酸为原料,经环化、氧化、缩合、加氢、酰化反应合成了6个新的具有茚结构的稠环缩氨基脲衍生物,总收率7%～9%。其结构经核磁共振氢谱和高分辨质谱确认正确。初步生物活性测试表明:大多数化合物对多种害虫具有很好的杀虫活性。7-氯-2,3,4a,5-四氢-2-[N-甲氧羰基-N-(4-三氟甲基苯基)氨基甲酰基]茚戊[1,2-e][1,3,4]口恶二嗪-4a-甲酸甲酯(Ⅻb)的活性略高于已商品化杀虫剂茚虫威。
Several new aromatic condensed-cyclic semicarbazone derivatives with the structure of indene were prepared from 4-chlorophenylacetic acid in 7% -9% yield, through cyclization, oxidation, condensation, hydrogenation, acylation, etc. Their structures were confirmed through 1HNMR and HRMS. Preliminary bioassay shows that most of them exhibited good activity toward various insects. Methyl 7-chloro-2,5-dihydro-2- [ [ （ methoxycarbonyl ） [ 4- （ trifluoromethyl ） -phenyl ~ amino ] carbonyl indeno[ 1,2-e ] [ 1,3,4 ] oxadiazine-4a （ 3H）-carboxylate （ XII b） even shows higher activity than Indoxacarb.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2013年第4期475-480,共6页
Fine Chemicals
关键词
缩氨基脲衍生物
杀虫活性
4-氯苯乙酸
semicarbazone derivatives
insecticidal activity
4-chlorophenylacetic acid
