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细胞研究中的金属配合物-核酸相互作用 被引量:3

Introduction of Metal Complex-Nucleic Acid Interactions into Cells
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摘要 金属配合物与核酸相互作用的探讨对新型抗癌金属药物的设计、核酸结构的特异识别和核酸水解断裂的研究一直起着巨大的推动作用。不仅如此,配合物与核酸的相互作用已被引入细胞生物学研究中。本文利用一些典型的研究结果,对配合物与核酸相互作用应用于胞内DNA定位成像,对胞内信号转导和表观遗传的影响,以及金属配合物作为非病毒基因载体进行了总结。 The exploration on metal complex-nucleic acid interactions plays key roles not only in rational design of both new metal-based anticancer drugs and effective hydrolytic cleaving agents of nucleic acids, but also in development of specific recognition probes of nucleic acid structures. Currently, the metal complex-nucleic acid interactions are being introduced into cell biological studies. For example, the intracellular localization imaging methods of nuclear and mitochondrial DNAs are being developed based on the DNA binding of ruthenium ( II ) complexes. The effects of metal complex binding to nucleic acids on intracellular signal transduetion and epigenetic inheritance have attracted a good deal of attention. The metal complexes that may act as nonviral nucleic acid carriers are being designed on the basis of their ability to condense nucleic acids. We review the important advances in investigation on the intracellular metal complex-nucleic acid interactions by utilization of typical cases.
出处 《化学进展》 SCIE CAS CSCD 北大核心 2013年第4期555-562,共8页 Progress in Chemistry
基金 国家自然科学基金项目(No.20971049 21072074)资助
关键词 金属配合物 细胞成像 表观遗传 信号转导 非病毒基因载体 metal complexes cell imaging epigenetic inheritance signal transduction non-viral gene vectors
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  • 1王晓勇(WangXY),郭子建(GuoZJ).化学进展,2009,21:836-845.
  • 2耿杰(GengJ),于海佳(YuHJ),张海元(ZhangHY),徐海霞(XuHX),曲晓刚(QuxG).化学进展),2009,5:68-74.
  • 3Liu CL, YuSW, LiDF, LiaoZR, SunX H, XuH B. Inorg Chem. , 2002, 41 : 913-922.
  • 4Liu C L, Wang M, Zhang T, Sun H Z. Coord. Chem. Rev. 2004, 248:147-168.
  • 5Liu C L, Wang L. Dalton Trans. , 2009, 38:227-239.
  • 6Zeglis B M, Pierre V C, Barton J K. Chem. Commun. , 2007,44 : 4565-4579.
  • 7Erkkila K E, Odom D T, Barton J K. Chem. Rev. , 1999, 99: 2777-2795.
  • 8Song H, Kaiser J T, Barton J K. Nat. Chem. , 2012, 4: 615- 620.
  • 9Niyazi H, Hall J P, O' Sullivan K, Winter G, Sorensen T, Kelly J M, Cardin C J. Nat. Chem. , 2012, 4:621-628.
  • 10Hall J F, O' Sullivan K, Naseer A, Smith 3 A, Kelly J M, Cardin C J. Proc. Natl. Acad. Sci. U. S. A. , 2011, 108: 17610-17614.

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  • 1卢洁,刘双语,潘雪梅,胡炜,朱平川.吡唑衍生物PTF及其金属配合物与鲑鱼精DNA相互作用研究[J].基因组学与应用生物学,2021,40(7):2530-2538. 被引量:1
  • 2周庆华,杨频.1,3-双(2-苯并咪唑基)-2-氧杂丙烷与锌配合物的合成、晶体结构及其与DNA作用方式的研究[J].化学学报,2006,64(8):793-798. 被引量:25
  • 3Verma IM, Somia N. Gene therapy vectors and their use in antitumour therapy. Nature, 1997, 389: 239-242.
  • 4Anderson WF. Human gene therapy. Nature, 1998, 392: 25-30.
  • 5Blessing T, Remy J-S, Behr J-P. Template oligomerization of DNA-bound cations produces calibrated nanometric particles. J Am Chem Soc, 1998, 120: 8519-8520.
  • 6Blessing T, Remy J-S, Behr J-P. Monomolecular collapse of plasmid DNA into stable virus-like-particles. Proc Natl Acad Sci USA, 1998, 95: 1427-1431.
  • 7Namiki Y, Fuchigami T, Tada N, Kawamura R. Nanomedicine for cancer: lipid-based nanostructures for drug delivery and monitoring. Acc Chem Res, 2011, 44: 1080-1093.
  • 8Son S, Namgung R, Kim J. Bioreducible polymers for gene silencing and delivery. Acc Chem Res, 2012, 45: 1100-1112.
  • 9Guo X, Huang L. Recent advances in nonviral vectors for gene delivery. Acc Chem Res, 2012, 45: 971-979.
  • 10Zheng M, Zhong YN, Meng FH. Lipoic acid modified low molecular weight polyethylenimine mediates nontoxic and highly potent in vitro gene transfection. Mol Pharm, 2011, 8: 2434-2443.

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