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稻瘟病菌中蛋白激酶CK2的功能预测分析

Rediction and Functional Analysis of Protein Kinase CK2 in Magnaporthe oryzae
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摘要 通过生物信息学分析,初步掌握了稻瘟病菌(Magnaporthe oryzae)中蛋白激酶CK2三亚基的结构特点,生物进化树分析表明CK2的蛋白序列在进化上的高度保守性;利用酵母同源比对的方法预测分析了稻瘟病菌中潜在的互作底物,揭示了CK2可能参与的生理生化过程,并且重点预测分析了CK2与小G蛋白Rho3之间的互作关系,为进一步揭示稻瘟病菌蛋白激酶CK2的功能及其参与调控的信号通路提供了理论基础。 Protein kinase CK2, a conservative serine/threonine kinase, is typically found in tetrameric complexes consisting of two catalytic subunits and two regulatory subunits. The structural features of CK2 in Magnaporthe oryzae were analyzed with bio-informatics. The cladograms analysis revealed that the protein sequences of CK2 is very conservative in the evolution process. Yeast homologous comparison implied that CK2 potential substrates were forecasted in M. oryzae , meaning CK2 participated in some the physiological and biochemical processes . The interaction between CK2 and Rho3 was emphasized. The study is a good way to further study the function and signal transduction pathway of protein kinase CK2 in M.oryzae.
作者 张连虎 林婕 翟珍珍 钟振晖 陈少华 张承康 王宗华 鲁国东
机构地区 福建农林大学植物保护学院 福建农林大学生命科学学院
出处 《热带作物学报》 CSCD 北大核心 2013年第3期459-465,共7页 Chinese Journal of Tropical Crops
基金 国家自然科学基金项目(No.30870103) 教育部科学技术研究重点项目(No.209065) 福建省教育厅重点项目(No.JA08056)
关键词 稻瘟病菌 蛋白激酶CK2 小G蛋白Rho3 生物信息学 信号转导 Magnaporthe oryzae Protein kinase CK2 Small G proteins Rho3 Bioinformatics Signal transduction
分类号 S435.111.1 [农业科学—农业昆虫与害虫防治]
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参考文献16

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二级参考文献38

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热带作物学报
2013年 第3期

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