2008年北京市新发乳腺癌病例超重和肥胖与乳腺癌的关系

Association of overweight and obesity with breast cancer

目的探讨超重、肥胖和乳腺癌之间的关系,为乳腺癌的防治提供科学依据。方法以2008年北京市3460例新发乳腺癌女性病例为研究对象,分析不同体质指数(BMI)乳腺癌病例的一般情况、临床和病理分期、病理特征。结果低体重、正常体重、超重和肥胖组绝经后乳腺癌病例所占比例分别为39.7%、40.2%、55.1%和59.6%,差异有统计学意义(P<0.05)。低体重、正常体重、超重和肥胖组乳腺癌家族史比例分别为4.6%、4.7%、5.8%和6.6%,差异有统计学意义(P<0.05)。低体重、正常体重、超重和肥胖组雌或孕激素受体阳性比例分别为68.3%、69.0%、73.4%和75.9%,差异有统计学意义(P<0.05)。肥胖组淋巴结转移、肿瘤直径等均高于低体重和正常体重组。结论超重和肥胖是乳腺癌发生、发展和预后的重要影响因素之一,为了更好地防治乳腺癌,应改善饮食结构、增加体育锻炼,预防肥胖的发生。

Objective To explore the association oi overweight and obesity with breast cancer and to prowde the basis for preventing breast cancer. Methods Thirty four hundred sixty female patients with primary breast cancer of Beijing in 2008 served as subjects. The BMI, clinical and pathological diagnosis were analyzed. Results The morbidities of post-menopausal breast cancer cases with under bodyweight, normal bodyweight, overweight and obesity were 39.7%, 40.2%, 55.1% and 59.6%, respectively, there were significant differences between groups （P〈0.05）. The morbidities of breast cancer cases with family history for under bodyweight, normal bodyweight, overweight and obesity were 4.6%, 4.7%, 5.8% and 6.6% ,respectively, there were significant differences between groups （P〈0.05）. The morbidities of breast cancer cases with positive estrogen/progesterone receptors for under bodyweight, normal bodyweight, overweight and obesity were 68.3%, 69.0%, 73.4% and 75.9%, respectively, there were significant differences between groups （P〈0.05）. In addition, the proportion of cases with lymph node metastasis and large tumor size in overweight and obesity group was significantly higher than that in under and normal weight groups. Conclusion Overweight and obesity is one of the most important risk factors for breast cancer. In order to prevent breast cancer, the diet and physical exercise should be improved.