儿童血清ghrelin水平与血脂、瘦素、脂联素及胰岛素关系的分析

Relationships between serum ghrelin and lipid profile and serum leptin,adiponectin,and insulin among children in Beijing,China

目的探讨儿童血清ghrelin水平与血脂、瘦素、脂联素及胰岛素的关系。方法采用多阶段随机抽样的方法,随机抽取879名8～10岁小学生作为调查对象。测量身高、体重、腰围,计算体质指数(BMI)、体脂百分比(%BF),测定血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖、ghrelin、脂联素、胰岛素及瘦素。结果随血清ghrelin水平的升高,体重、腰围、BMI、%BF、血清瘦素水平逐渐降低(P<0.0001),血清HDL-C水平呈现逐渐增高的趋势(P<0.0001),血清TC、胰岛素和脂联素水平变化趋势不明显;与ghrelin密切相关的指标为体成分指标,包括身高、体重、腰围、BMI、%BF以及瘦素,其次是血脂代谢指标,包括TG、HDL-C、TC、LDL-C,第三是血糖代谢指标,包括空腹血糖和胰岛素。结论ghrelin与体成分指标、瘦素、脂联素、胰岛素以及血脂有不同程度的关联,但和身高、体重、腰围、BMI、%BF以及瘦素的相关最为密切。

Objective To study the relationship between serum ghrelin and lipid profile and serum leptin, adiponectin, and insulin among children in Beijing. Methods A total of 879 pupils aged 8 - 10 years were randomly selected. Height, body weight, waist circumference, body mass index （BMI）, body fat percentage （%BF） , blood lipid, serum leptin, insulin, adiponectin and ghrelin were measured in all samples. Results Ghrelin associated negatively with body weight, waist circumference, BMI, %BF, serum leptin level and positively with HDL-C. Factor analysis has shown five factors which were sufficient to explain correlations between variables-body composition and leptin, dyslipidemia, glucose metabolism and adiponectin. Conclusion Serum ghrelin level correlated strongly with body weight, waist circumference, BMI, %BF and leptin, Our finding suggested significantly increased leptin levels following decreased ghrelin levels could mostly disordered adipose metabolism at early obesity in children.