放射性^(131)碘治疗甲亢性心脏病临床疗效观察

Therapeutic efficacy of radioactive iodine-131 in treatment of hyperthyroid heart disease

目的探讨放射性131碘在治疗甲状腺功能亢进性心脏病的近期疗效。方法 120例患者通过临床确诊为甲亢性心脏病后进行放射性131碘治疗,后观察其12个月后的疗效,并分别记录其3、6、12个月时甲状腺激素血清水平,对120例的治疗数据进行统计学分析。结果通过放射性131碘的治疗12个月后的甲亢的总有效率为92.5%,治愈率为66.6%;其中包括甲亢性心脏病痊愈64例,痊愈12例,无效2例,甲减11例,治愈率达73.3%。结论放射性131碘在治疗甲亢及甲亢性心脏病的治疗中疗效显著,但由于仍然存在临床上的无效病例,应在治疗的同时进行综合性的治疗,并进一步探讨放射性131碘临床副作用。

Objective To investigate the short-term therapeutic efficacy of radioactive iodine-131 in the treatment of hyperthyroid heart disease. Methods A total of 120 patients with a confirmed diagnosis of hyperthyroid heart disease received treatment with radioactive iodine-131. The treatment outcomes were observe 12 months later, and the serum thyroid hormone levels were recorded after 3, 6, and 12 months of treatment. The treatment data of the 120 cases were subjected to statistical analysis. Results After 12 months of treatment with radiOactive iodine- 131, for hyperthyroidism, the overall response rate was 92.5%, and the cure rate was 66.6%; for hyperthyroid heart disease, 64 cases were cured, 12 cases recovered, 2 cases showed no response, and 11 cases developed hypothyroidism, with a cure rate was 73.3%. Conclusion Radioactive iodine-131 has good therapeutic efficacy in the treatment of hyperthyroidism and hyperthyroid heart disease. But there are still patients who have no response to the treatment, so comprehensive treatment should be performed, and the side effects of radioactive iodine-131 should be further investigated.