茯苓、茯神水煎液对小鼠镇静催眠作用的比较研究

Study on Sedative-Hypnotic Effect of Poria Cocos and Fushen Water Decoction

目的观察比较茯苓、茯神水煎液对小鼠的镇静催眠作用。方法通过直接睡眠实验、协同戊巴比妥钠作用实验,以及抗惊厥实验,观察茯苓、茯神水煎液对小鼠的镇静催眠作用。结果茯苓、茯神水煎液对小鼠的直接睡眠作用较弱;茯苓、茯神水煎液可明显增加戊巴比妥钠阈下剂量的动物入睡率,除茯苓水煎液小剂量组外,其余各组均能明显延长阈上戊巴比妥钠小鼠睡眠时间;茯神水煎液有一定的抗惊厥作用。结论茯苓、茯神水煎液具有一定的镇静催眠作用,且茯神强于茯苓。

Objectve Study on the sedative-hypnotic effect of Poria cocos and Fushen water decoction.Methods Straightforward hypnosis experiment,pentobarbital sodium-induced sleep and anticonvulsive experiments were made to observe the effects of Poria cocos and Fushen water decoction on sedation and hypnosis in mice.Results The Poria cocos and Fushen water decoction showed a weak role of Straightforward hypnosis,but significantly increased the ratio of sleeping which was caused by pentobarbital sodium,and protracted the sleeping time except low dose group of the Poria cocos water decoction.Besides,Fushen group showed some anticonvulsant action only.Conclusion The Poria cocos and Fushen water decoction have some sedative-hypnotic action,and the Fushen has more obvious effects than the Poria cocos.