辛伐他汀与贝那普利联用治疗血脂正常的轻中度原发性高血压的临床观察

Clinical observation of Simvastatin therapy with benazepril in the treatment of normolipemic patients with mild and moderate essential hypertension

目的探讨辛伐他汀与贝那普利联用治疗血脂正常的轻中度原发性高血压的临床疗效及安全性。方法将100例血脂正常的轻中度原发性高血压患者随机分为对照组和观察组(各50例),对照组给予贝那普利治疗,观察组给予辛伐他汀联合贝那普利治疗,治疗12周后,观察比较两组患者的临床疗效及不良反应。结果治疗12周后,两组患者血压水平均有改善,与治疗前比较,其差异有统计学意义(P<0.05);治疗后观察组患者血压好于对照组,组间比较差异有统计学意义(P<0.05);治疗期间所有患者均无严重不良反应。结论辛伐他汀联合贝那普利治疗血脂正常的轻中度原发性高血压,临床治疗显著优于单一用药,无严重不良反应,是一种理想的降压治疗方案。

Objective To explore the effect and safety of Simvastatin therapy with benazepril in the treatment of normolipemic patients with mild and moderate essential hypertension. Methods A hundred cases of patients with essential hypertension and normolipemic were randomly assigned into the control group （ 50 cases） and the investigation group （ 50 cases） ; The former took benazepril, the latter took Simvastatin and benazepril. After 12 weeks of treatment, the effect and safety were observed and compared in both groups. Results Blood pressure levels decreased after treatment in both groups. There were significant difference between two groups（ P 〈 0.05 ） ;Blood pressure in the investigation were better than those in the control group. There were significant difference between two groups （ P 〈 0.05 ） ; During twelve weeks of observation,all the patients had no serious adverse reaction. Conclusion Clinical effects of simvastatin and benazepril for treating patients with essential hypertension and normolipemic are better than those in the control group, and there is no serious ad- verse effect, which is being recommended in clinical practice.