2011年我院403例药品不良反应报告分析

ADR report of 403 cases in a hospital in 2011

目的了解不良反应(ADR)发生的特点,为临床安全,合理用药提供参考。方法对该院2011年1月—2011年12月收集到的403例药品不良反应报告进行统计学分析。结果 403例药品不良反应报告中,男女之比1∶1.178 4,60岁以上老年患者发生率最多,占37.47%;其中抗感染药物占首位,34.04%。静脉给药方式为主要途径,100%。临床表现以神经系统损害最常见。严重的不良反应13例,未发生新的不良反应。结论应加强ADR的监测,有ADR征兆时及时处理,以免发生更严重的ADR。

Objective To investigate the incidence of adverse drug reactions （ADR） occurring in First People＇ s Hospital of Wuhu for ref- erence of clinical rational drug administration. Method 403 ADR cases reported between January 2011 to December 2011 were statisti- cally analyzed. Results In 403 cases of ADR reports,the ratio of male to female was 1： 1. 178 4. The highest incidence oceurred in pa- tients 60 years of age or older, accounting for 37.47 % ; Most ADR were caused by antibacterial drugs, accounting for 34.04% of the total number. Intravenous dripping was used as the main way of infusion, 100%. The common involved organs and system was the nervous sys- tem. There were 13 cases of serious adverse events,without any new adverse reactions. Conclusion ADR monitoring should be empha- sized, countermeasures should be conducted in time to avoid serious ADR when there are signs of ADR.