胰高血糖素在冠心病心力衰竭患者血浆中水平的变化和临床意义(英文)

Changes of plasma glucagon level in patients with heart failure caused by coronary heart disease and its clinical significance

目的:探讨冠心病所致心力衰竭患者血浆中胰高血糖素水平的变化及其临床意义。方法:选择冠心病所致心力衰竭患者30例作为心力衰竭组,年龄性别与之相匹配的门诊健康体检者30例作为正常对照组。对心力衰竭病人按中国慢性心力衰竭诊治指南给予强心、利尿、扩血管等综合治疗7～10 d,观察其治疗前后胰岛血糖素水平的变化。结果:治疗前,心力衰竭组血浆胰高血糖素水平明显高于正常对照组[(205.67±120.22)ng/L比(90.53±20.5)ng/L,P<0.05]。治疗后,心力衰竭组血浆胰高血糖素水平为(120.42±30.33)ng/L,较治疗前明显下降(P<0.05)。结论:心力衰竭患者血浆胰高血糖素水平明显升高,症状控制后又逐渐降低至接近正常水平,或许胰高血糖素可以作为临床判断冠心病心力衰竭患者病情变化的指标之一。

Objective.. To investigate changes of plasma glucagon level in patients with heart failure （HF） caused by coronary heart disease （CHD） and its clinical significance. Methods.. A total of 30 HF patients caused by CHD were selected as HF group, another 30 healthy subjects with corresponding age and gender were regard as normal control group. HF patients re- ceived comprehensive therapy of enhancing myocardial contractility, diuretic and vasodilator of 7-10d according to Chinese diagnostic and treatment guideline of chronic heart failure. Changes of glucagon level before and after treatment were ob- served. Results：Before treatment,plasma level of glucagon in HF group was significantly higher than that of normal control group [（205.67±120. 22） ng/L vs. （90. 53±20.5） ng/L,P〈0.05]. After treatment,plasma level of glucagon [（120, 42 ± 30. 33） ng/L] significantly decreased than before treatment （P（0. 05） in HF group. Conclusion： Plasma glucagon signifi- cantly increases in patients with l^eart failure and gradually decreases to near normal level after treatment. Glucagon level may be regard as one of indexes judging patients＂ condition.