阿托伐他汀对血脂正常高血压患者血压和高敏C反应蛋白的影响

Influence of atorvastatin on blood pressure and high sensitive C reactive protein in patients with essential hypertension and normal blood lipidemia

目的:观察阿托伐他汀对血脂正常高血压患者血压和高敏C反应蛋白(hsCRP)的影响。方法:62例血脂正常高血压患者被随机均分为常规治疗组和阿托伐他汀组(在常规降压治疗基础上加服阿托伐他汀20mg/d),治疗12周,分别检测治疗前后患者血压和血清hsCRP水平。结果:治疗后与常规治疗组比较,阿托伐他汀组患者血压[收缩压:(137.35±13.66)mmHg比(132.12±12.68)mmHg,舒张压:(86.61±9.16)mmHg比(81.29±8.92)mmHg]和血清hsCRP[(7.54±1.36)mg/L比(5.07±1.06)mg/L]水平均明显降低(P<0.05或<0.01)。结论:阿托伐他汀对血脂正常高血压有协同降压作用,同时降低患者血清高敏C反应蛋白水平,提示其作用机制可能与抑制炎症反应有关。

Objective： To observe influence of atorvastatin on blood pressure and high sensitive C reactive protein （hsCRP） in patients with essential hypertension （EH） and normal blood lipidemia. Methods： A total of 62 EH pa- tients with normal blood lipidemia were randomly and equally divided into routine treatment group and atorvastatingroup （received atorvastatin 20 mg/d additionally based on routine antihypertensive therapy）, and they were treated for 12 weeks. Blood pressure and serum hsCRP level were measured before and after treatment in two groups. Resuits： Compared with routine treatment group after treatment, there were significant decrease in blood pressure [systolic blood pressure： （137.35 ± 13.66） mmHg vs. （132.12 ± 12.68） mmHg, diastolic blood pressure.. （86. 61± 9.16） mmHg vs. （81.29 ±8.92） mmHg] and serum hsCRP level [ （7.54 ± 1.36） mg/L vs. （5.07 ± 1.06） mg/L] in atorvastatin group, P〈0.05 or d〈.01. Conclusion： Atorvastatin possesses synergistic hypotensive effect in patients with essential hypertension and normal blood lipidemia, and simultaneously decreases serum level of high sensitive C reactive protein, suggesting that its mechanism my be related with inhibition of inflammatory reaction.