功能性消化不良的发病机制

Pathogenesis of functional dyspepsia

功能性消化不良(functional dyspepsia,FD)是临床上最常见的一种功能性胃肠病,且其具有慢性、复发性、难以缓解性,因而不仅明显影响患者的生活质量,而且也造成了相当高的医疗费用支出.而FD疾病具体的发病机制一直是困扰众多学者的难题.目前多数学者认为胃动力异常、内脏高敏感性、社会心理学因素、幽门螺杆菌、遗传、过度的胃酸分泌、环境、饮食及生活方式与FD的发生有关,且脑-肠轴、自主神经系统和胃肠激素在其中可能起着重要的作用.本文旨在对近年来有关FD发病机制的研究进展做一综述,并对其中可能存在的潜在联系做一分析.

Functional dyspepsia （FD） is one of the most common clinical functional gastrointestinal disorders. As a chronic, relapsing and remitting disorder, FD not only significantly affects the quality of life of patients but also causes very high medical expenses. However, the specific pathogenesis of FD has always been a big problem for gastroenterologists. Recently, motility abnormalities, visceral hypersensitivity, psycho-social factors, Helicobacter pylori, genetic factors, excessive gastric acid secretion, environment, diet, and lifestyle have been proposed to explain the pathogenesis of FD, of which the brain-gut axis, autonomic nervous system , gastrointes-tinal hormones may play an important role. In this paper, we review the recent progress in thepathogenesis of FD.