新型有机硅季鏻盐抗菌剂的合成及应用研究

Synthesis and application of novel silicone quaternary phosphonium salt antibacterial agent

以三苯基膦和氯丙基三乙氧基硅烷为原料,通过SN2反应合成氯丙基三乙氧基硅烷季鏻盐.考察了溶剂种类和用量、反应温度、反应时间、反应物配比等因素对反应转化率的影响,采用红外光谱和核磁共振谱表征了产物.结果表明,合成有机硅季鏻盐的最佳工艺为:以40 mL苯甲醇为溶剂,n(三苯基膦)∶n(硅烷)=1∶1.1,135℃反应27 h.通过浸轧将产品用于棉织物的整理,测得整理织物对大肠杆菌和金黄色葡萄球菌的抑菌率均在80%以上,说明有机硅季鏻盐确实能够提高织物的抗菌性能.研究还表明,整理织物具有一定的耐洗性.

R-chloropropyl triethoxysilane quaternary phosphonium salt was synthesized through SN2 reac- tion, using triphenylphosphine and γ-chloropropyl triethoxysilane as raw materials. The effects of the type and amount of solvent, reaction temperature, reaction time and the ratio of reactants on conversion rate of reac- tion were investigated. The product was characterized by the structure using FTIR and NMR. The results showed that the optimal reaction conditions were as follows： reaction medium was 40 mL benzyl alcohol, mo- lar ratio of triphenylphosphine to γ-chloropropyl triethoxysilane was 1 ： 1.1, reaction temperature was 135 % and reaction time was 27 h. The cotton fabric was treated with quaternary phosphonium salt by padding meth- od. The inhibition rates of the treated cotton fabric to E. coli and S. aureus were both more than 80%, which in- dicated that the quaternary phosphonium salt could increase the antibacterial property of the fabric. Further- more, the results showed that the treated fabric had certain washing durability.