不同含漱液预防活动期红斑狼疮患者口腔及肺部感染的临床研究

Preventing oral and lung infections in patients with active systemic lupus erythematosus:comparison of the efficacy of three different mouthrinse solutions

目的探讨不同含漱液预防活动期红斑狼疮患者口腔及肺部感染的作用。方法将90例活动期红斑狼疮患者随机分为三组各30例,均于晨起刷牙后、三餐后、睡前刷牙后5个时间点分别以益口、庆大霉素+制霉菌素、生理盐水含漱,每次不少于3min;比较三组口腔异味、真菌感染及肺部感染发生情况。结果三组口腔异味发生率、口腔真菌阳性率及肺部感染发生率比较,差异有统计学意义(均P<0.01)。结论庆大霉素+制霉菌素和益口含漱液均能有效降低活动期红斑狼疮患者口腔真菌和肺部感染发生率;且益口含漱液去除口腔异味效果最优。

Objective To prevent oral and lung infections by using different mouthrinse solutions for patients with active systemic lupus erythematosus （SLE）. Methods Ninety patients with active SLE were randomly divided into three groups of 30 each, gargling their mouth with Yi Kou, admixture of gentamicin and nystatin, or normal saline respectively, in the morning after brushing their teeth, after meals and at bedtime after brushing. Each gargle lasted at least 3 min. The rates of bad breath, fungal infections and lung infections among the three groups were compared. Results The rates of bad breath, oral fungal infections and lung infections among the three groups had significant differences （P^0.01 for all）. Conclusion Mouth gargle with admixture of gentamicin and nystatin, or with Yi Kou could effectively reduce rates of oral fungal and lung infections in patients with active SLE; and Yi Kou is the best in fighting bad breath.