尿激酶与低剂量rt-PA溶栓治疗急性肺栓塞疗效对比分析

Efficacy of Urokinase and Low dose Reteplase in Treatment of Acute Pulmonary Thromboembolism: a Comparative Study

目的:分析比较尿激酶与rt-PA治疗急性肺栓塞的临床疗效,寻找最佳治疗方案。方法:回顾性分析我科抢救的急性肺栓塞患者的临床资料,按照治疗方式不同分为两组,观察组采用50mg小剂量rt-PA治疗,对照组采用尿激酶治疗,比较两组患者的疗效及不同时间肺动脉压的变化。结果:观察组总有效率显著高于对照组,且溶栓治疗后短时间内,观察组肺动脉收缩压降低较对照组更为明显(P<0.05);同时观察组动脉收缩压、动脉血氧分压均显著高于对照组(P<0.05)。两组患者均有出血性并发症,但对照组出血性并发症显著性高于观察组。结论:50mg rt-PA治疗急性肺栓塞可在短时间内改善急性肺栓塞对于心功能的影响以及组织缺氧状态,疗效肯定,临床使用较为安全。

Objective： To compare the efficacy of low dose reteplase and urokinase in the treatment of acute pulmonary thromboembolism （ PTE ） in emergency. Method： The retrospective study was made between the patients with acute massive laTE . All those patients were treated by intravenous thrombolysis with reteplase（ observation group） or urokinase （ control group）. The thrombolysis efficacy, bleeding incidence and pulmonary artery pressure were measured. Result： In the observation group, the emergency thrombolysis effective rate was higer than the control group. The observation group has better pulmonary artery pressure, systolic pressure and arterial oxygen pressure. And the observation group has less bl trol group. Conclusion： The low dose reteplase thrombolysis therapy are safe and acute PTE. eeding incidence than con- effective in the treatment of acute PTE.