摘要
目的探讨Graves病(GD)与ABO血型的关系。方法调查临沂市汉族人群的ABO血型分布及汉族GD患者的ABO血型分布,分析比较A型、B型、AB型、O型在不同人群中的构成比差异,比较各种血型患GD的相对危险度(OR)。用玻片凝集法检测ABO血型。用电化学发光法测病人的FT3、FT4、TSH、TPOAb、TSHR-Ab。结果临沂市汉族人群ABO血型的分布特点为:B型(30.64%)>A型(30.02%)>O型(28.88%)>AB型(10.46%);临沂市汉族GD患者的血型分布特点与其存在显著差异(P<0.0001)。患GD的OR为:AB型(1.95)(P<0.001)>O型(1.44)(P<0.001)>B型(1.1)>A型(1.0)。结论就血型而言,临沂市汉族人AB血型和O血型者发生GD的风险高,AB型较O型者风险更高。
Objective To investigate the relationship between Graves＇ disease （GD）and the ABO blood type. Methods To investigate the ABO blood type distribution of the Han population and of the GD patients, to compare the difference in the constituent ratios of A, B, AB and O blood types, and to explore the difference in the relative risk （OR） of GD in people of different blood types. The ABO blood types were detected by slide agglutination,and patients＇ FT3, FT4,TSH,TPOAb and TSHR-Ab were measured by the electrochemiluminescence method. Results The characteristic of blood type distribution of Han population in Linyi City was that the constituent ratios constituent ratios of A, B, AB and O blood types was as follows： Type B （30.64%） 〉Type A （30.02%） 〉Type O （28. 88% ） 〉 Type AB （ 10.46% ）. There existed significant difference between the characteristic of blood type distribution in GD patients and the distribution of Han population in Linyi City （ P 〈 0. 0001 ）. The OR of GD in people of different blood types was as follows ： Type AB （ 1.95 ） （ P 〈0.001） Type 〉0（1.44）（P 〈0.001） 〉 TypeB（1.1） 〉 Type A （ 1.0 ）. Conclusion The person with AB or 0 blood type has the high risk of GD in Linyi＇ s Han population, and the person with Type AB has higher risk of GD than the person with Type O.
基金
临沂市科技发展计划项目(No.201013021)
