广泛性焦虑症与抑郁症患者皮肤交感反应对照研究

Comparison of skin sympathetic reaction in patients with generalized anxiety disorder and with major depression disorder

目的:探讨广泛性焦虑症(GAD)与抑郁症(MDD)患者皮肤交感反应(SSR)的差异。方法:对30例GAD患者、30例MDD患者,分别在治疗前及治疗8周后检测SSR的潜伏期与波幅,并与30例正常对照组(HC)比较。结果:GAD组治疗前SSR潜伏期低于HC组,波幅明显高于HC组,差异均有显著性意义(P<0.05);MDD组治疗前潜伏期比HC组明显延长,波幅明显低平,差异均有显著性意义(P<0.05),而且有2例未引出波形。经治疗后,GAD组潜伏期水平较治疗前延长,接近于对照组水平;波幅较治疗前降低,但高于对照组(P>0.05);MDD组潜伏期较治疗前降低(P<0.05),差异均有显著性意义。MDD组的SSR潜伏期明显延长,GAD组潜伏期缩短,两组比较差异有统计学意义(P<0.05);MDD组波幅明显低平,而GAD组波幅明显增高,两组比较差异有统计学意义(P<0.001)。相关分析显示,SSR各参数与HAMA和HAMD呈正相关,相关系数分别为0.57和0.73。结论:GAD与MDD在SSR的电生理检测方面有显著性差异。

Objective： To compare skin sympathetic response （SSR） between patients with generalized anxiety disorder（GAD） and patients with major depression disorder（MDD）. Methods： The latency and amplitude of SSR wave were measured in 30 GAD patients and 30 MDD patients,before and after 8-week treatment of anti-anxiety or anti-depression drugs. Thirty age and sex-matched healthy subjects served as healthy controls （HC）. Results： Before the treatment, the latency of SSR in GAD patients was significantly shorter than that in HC group, while the amplitude was significantly higher than that in the HC （ P 〈 0.05 ）. In MDD group, the latency before the treatment was significantly longer than that in the HC, while the amplitude was significantly lower than that in the HC （ P 〈 0.05 ）. After treatment, the latency of SSR in GAD group was extended compared to the baseline level, and close to the level of the HC. The amplitude of SSR in GAD group became lower after treatment, but still higher than that of control group. The latency of SSR in MDD patients was significantly shorter after treatment compared to baseline level（P 〈0.05）. In addition,the latency of SSR in MDD group was still longer than that in GAD group （ P 〈 0.05 ） ; meanwhile, the amplitude of SSR in MDD group was significantly lower that in GAD group （P 〈 0. 001 ）. SSR parameters were positively correlated with HAMA and HAMD scores with a correlation coefficient of 0. 57 and 0. 73, respectively. Conclusion： There are significant differences in SSR parameters between patients with GAD and patients with MDD, indicating that SSR can be used as an objective index to distinguish anxiety from depression.