沿海地区钠盐排泄和血管损害关系的调查

Relationship between sodium excretion and vascular injury in coastal area

目的:调查中国东南部某沿海地区钠盐的摄入量及探讨反映钠盐摄入量的尿钠肌酐比值(Na/Cr)和尿白蛋白肌酐比值(UACR)、视网膜中央动脉直径(CRAE)、臂踝脉搏波传导速度(baPWV)间关系。方法:横断面调查2 456例尿钠、尿肌酐、尿微量白蛋白、CRAE、baPWV,探讨Na/Cr和UACR、CRAE、baPWV之间的关系。结果:UACR、CRAE、baPWV在Na/Cr四分位分组Q1～Q4间比较差异有统计学意义(P<0.01);UACR、CRAE、baPWV异常百分率在Q1～Q4间比较差异有统计学意义(P<0.01);控制了混杂因素后,二元Logistic回归显示,Na/Cr是UACR和CRAE独立影响因素(P<0.01);多元线性回归显示收缩压、年龄、BMI、腰围、TG是baPWV的影响因素,而Na/Cr不是baPWV的影响因素。结论:高钠膳食与人群小血管的损害(UACR、CRAE)相关。

Objective：To investigate sodium intake and the relationship among sodium intake indices including the ratio of urinary sodium to creatinine（Na/Cr）,the ratio of urinary albumin to creatinine（UACR）,central retinal artery equivalent（CRAE）,brachial ankle pulse wave velocity（baPWV）. Method：For all the 2 456 objects,we measured Na/Cr,UACR,CRAE,baPWV and analysed the relationship among Na/Cr and UACR,CRAE,baPWV in this cross section survey. Result：UACR,CRAE,baPWV were significant different in the Q1-Q4 groups of Na/Cr（P0.01）;The abnormal rates of UACR,CRAE,baPWV were significant different in the Q1-Q4 groups of Na/Cr（P0.01）;Controlled the confounding variables,Logistic regression analysis showed that Na/Cr was the independent influencing factor of UACR and CRAE（P0.01）;Multiple stepwise regression analysis showed that systolic blood pressure,age,BMI,waist circumference,triglyceride level were the influence factors of baPWV,but Na/Cr was not the risk factor of baPWV. Conclusion：High sodium intake is related with the indices of the microvessel injury（UACR and CRAE）.