mPEG-b-PLGA胶束薄膜的制备及其摩擦学行为研究

Formation and Tribological Study of mPEG-b-PLGA Micelles Film

采用层层组装(layer by layer,LBL)方法,以氢键结合方式,将聚乙二醇-b-聚乳酸聚乙醇酸(mPEG-b-PLGA)胶束与聚丙烯酸(PAA)层层交替沉积到硅基底上,分别用接触角测量仪,椭圆偏光测厚仪,X光电子能谱及原子力显微镜等对聚合物胶束自组装薄膜的结构进行了表征,用UMT-2对薄膜的摩擦学特性进行了表征.沉积到基底表面的胶束薄膜能够稳定附着,且具有良好的减摩效果,有望作为导尿管或体内植入器件表面的抗炎、润滑多功能涂层.

In this paper,methoxy poly（ethylene glycol）-block-poly（lactic-co-glycolic acid）（mPEG-b-PLGA） micelles and poly（acrylic acid）（PAA） layers were alternately deposited on the silicon substrate,linked by hydrogen bonds.The structure of the micelles films were characterized by contact angle measurements,ellipsometric thickness measurements and X-ray photoelectronic spectroscopy,atomic force microscopy.Anti-wear properties of the films were also evaluated on a ball-on-plate tribometer.It was found that the mPEG-b-of PLGA micelle films were uniformly deposited and offered excellent lubrication.There is a possibility of such thin films as anti-inflaming and lubricating coating used on catheter or device implanted in vivo.