儿童过敏性紫癜肾损害相关危险因素分析

CORRELATED FACTORS OF RENAL INJURY IN CHILDREN WITH HENOCH-SCHONLEIN PURPURA

目的:探讨儿童过敏性紫癜(HSP)继发肾损害(HSPN)的相关危险因素,以便早期防治干预。方法:对我院儿科住院的100例初发无肾损害的HSP患儿为研究对象进行随访。除尿常规外,对患儿的年龄、性别、紫癜持续时间、关节肿痛、腹痛症状、消化道出血、外周血白细胞计数、血小板计数八项可能的相关危险因素为随访内容。所得资料应用生存分析加COX回归作多元回归分析。结果:随访100例HSP,继发HSPN 54例,失访3例,删失43例。经分析显示:年龄和消化道出血的B值分别为0.147和0.649,经Wald检验,分别P<0.01和P<0.05,差异均有统计学意义。结论:年龄越大、有消化道出血是HSP继发HSPN的危险因素。

Objective：To study the clinical correlated factors of renal involvement in Henoch- Schonlein purpura（HSP）. Methods ：The analysis was performed in 100 patients with HSP admitted in our hospital. The 8 clinical parameters were selected for analysis： age, sex, abdominal pain, gastrointestinal bleeding, persistent purpura, arthritis and white blood cell count and platelets count in peripheral. Factors were analysis using COX regression model and survival analysis. Results：Evidence of nephritis was detected in 54 patients, 3 were lost, 43 were interval-censored. After analysis. The univariate analysis revealed that age（ B = O. 147 ;P〈0.01 ） and gastrointestinal bleeding（ B = 0. 649 ;P〈 0.05 ） were all associated with increased incidence of renal involvement. Conclusions ： Age and gastrointestinal bleeding were prognostic factors of renal involvement.