变应性鼻炎患者脱敏治疗前后IFN-γ和IgE及IL-4水平变化的研究

The serum level transformation of IFN-γ,IL-4 and IgE before and after SIT in patients with allergic rhinitis

目的:探讨变应性鼻炎患者脱敏疗效及对血清干扰素γ(IFN-γ)、IL-4、总IgE及特异性IgE的影响。方法:对40例变应性鼻炎患者变应原特异性免疫治疗前和治疗2年后分别检测血清中IFN-γ、IL-4、总IgE及特异性IgE的水平,观察症状改善情况,并与20例正常对照者进行比较。结果:脱敏治疗2年症状改善有效率为85%。治疗后血清IFN-γ水平明显增高,IL-4、总IgE水平明显降低,治疗前后差异有统计学意义(P<0.01),而特异性IgE治疗前后无显著差异(P>0.05)。结论:脱敏治疗可调节变应性鼻炎患者血清IFN-γ、IgE和IL-4水平,降低总IgE水平,并可有效控制临床症状,但特异性IgE变化不明显,其在脱敏治疗中的作用有待进一步明确。

Objective：To assess the efficacy and the transformation of IFN-γ,IL-4,total IgE and specific IgE before and after specific immune therapy（SIT） in patients with allergic rhinitis.Method：The subjective symptom and levels of IFN-γ,IL-4,total IgE and specific IgE were observed in 40 patients with allergic rhinitis before and after SIT.Result：Total effective rate in patients after SIT was 85%.There＇s no significant difference between the levels of specific IgE before and after SIT（P0.05）,while the levels of IL-4 and total IgE were significantly lower,the levels of IFN-γ were significantly higher pre than that of post SIT.Conclusion：SIT is safe and effective,and can regulate the levels of IFN-γ,IgE and IL-4.But the role of specific IgE in SIT is still unknown.