细菌生物膜与慢性鼻-鼻窦炎发病机制的研究进展

Research progresses on the pathogenesis of bacterial biofilm in chronic rhinosinusitis

慢性鼻-鼻窦炎（chronic rhinosinusitis,CRS）是耳鼻咽喉科的常见疾病,也是全身常见的慢性疾病之一。CRS主要是感染（特别是细菌生物膜作用）、超抗原、鼻内结构异常和增生物、变态反应、黏液纤毛功能障碍、免疫功能低下和神经内分泌失调等相互作用的结果。近年来对细菌生物膜的研究越来越多,本文对细菌生物膜及其在CRS发病机制的研究进展作一综述。

The role of bacterial biofilms in the chronic diseases has been recognized more and more.The experts in the centers for disease control and prevention of the United States estimate that 65% of human bacterial infection is involved with the biofilms.In the recent study,it has been proved that there is a high correlation between the bacterial biofilm and the pathogenesis and prognosis of chronic rhinosinusitis（CRS）.In order to elucidate the role of bacteria films in the pathogenesis of CRS,we reviewed various method of testing the bacterial biofilms in CRS,and summarized the related researches.Based on the detection researches and summaries,we conclude that bacterial biofilm can contribute to the continuance and development（diffusion and repeated） of CRS.It can lead to the continuous inflammation by influencing the immune system of the mucous membrane.While there is little research on the bacterial biofilm,further researches will be needed for the exact mechanism of the bacterial biofilm in CRS,in order to find more effective therapeutic method and targets.