阿片耐药机制的研究进展
摘要
疼痛是多种疾病的症状之一。阿片类制剂可选择性地抑制痛觉，用于治疗躯体及内脏疼痛。但是此类药反复使用容易产生耐药，越来越多的证据表明阿片受体激动剂可促进脊髓神经胶质的活化，引导促炎细胞因子与趋化因子的合成与释放，导致阿片耐受的产生[1]。阿片耐药的机制十分复杂，本文将就其发生机制作一综述。
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2013年第4期429-431,共3页
Chinese Journal of Emergency Medicine
基金
北京市科技计划项目（京G-2011-07）
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