消栓通脉汤对血瘀湿阻证深静脉血栓形成血管内皮功能的影响

Influence on Vascular Endothelial Function of Blood Stasis and Dampness Retention Syndrome of Deep Venous Thrombosis with Xiaoshuantongmai(消栓通脉)Decoction

目的:观察消栓通脉汤对深静脉血栓形成血瘀湿阻证患者血管内皮功能的影响。方法:将60例下肢深静脉血栓形成血瘀湿阻证患者随机分为治疗组和对照组各30例,两组均应用溶栓、活血化瘀等基础治疗,治疗组30例同时服用消栓通脉汤,30d后进行疗效比较并观察TXB2、6-keto-PGF1α的变化。结果:治疗组临床治愈率高于对照组(33%vs10%,P<0.05),与对照组比较,治疗组TXB2含量显著降低(P<0.01),6-keto-PGF1α含量显著升高(P<0.01)。结论:消栓通脉汤对深静脉血栓形成血瘀湿阻证患者血管内皮功能有保护作用。

Objective To observe the influence on vascular endothelial function of blood stasis and damp- ness retention syndrome of deep venous thromhosis（DVT） with Xiaoshuantongmai Decoction. Methods Sixty patients were divided randomly into two groups. The treatment group including 30 cases was treated with Xiaosh- uantongmai Decoction, and the control group including 30 cases were treated without decoction. Both groups were given the basic therapy including thrombolysis and activating blood to resolve stagnation. The clinical ef- fect and the changes of TXB2 6-keto-PGF1 et were observed before treatment and 30 days after treatment. Results In the treatment group, 10 patients were cured and the recovery rate was 33%. While in the control group, 3 patients were cured and the recovery rate was 10%. The treatment group was obviously superior to the control group in therapeutic effect（P〈 0.05）, Comparing with control group, TXB2 content of the treatment group significantly reduced（P 〈 0.01）, while 6-keto-PGF1 ct content significantly increased（P 〈 0.01）. Conclusion Xiaoshuantongmai Decoction shows protective effect to vascular endothelial function for the patients with blood stasis and dampness retention syndrome of DVT.