小剂量红霉素联合游离氨基酸配方奶治疗早产儿喂养不耐受疗效观察

The clinical effects of low-dose erythromycin with amino acid based-formula on treatment of feeding intolerance in premature infants

目的探讨小剂量红霉素联合游离氨基酸配方奶治疗早产儿喂养不耐受的临床疗效。方法 2009年8月至2011年9月新生儿重症监护室收治的喂养不耐受早产儿108例,根据先后治疗措施的不同分为常规组、小剂量红霉素组(红霉素组)和小剂量红霉素联合游离氨基酸配方奶组(氨基酸配方组),比较三组早产儿喂养不耐受症状消退时间、体质量增长情况及静脉营养天数。结果与常规组比较,红霉素组及氨基酸配方组早产儿喂养不耐受症状消退时间、理想体质量增长时间、静脉营养天数及达到全肠内喂养时间显著缩短,氨基酸配方组最短,差异均有统计学意义(P<0.01)。结论小剂量红霉素联合游离氨基酸配方奶能改善早产儿喂养不耐受。

Objective To study the clinical effects of low-dose erythromycin with amino acid based-formula on treat- ment of feeding intolerance in premature infants. Methods A total of 108 premature infants with feeding intolerance admit- ted to neonatal intensive care unit from Aug. 2009 to Sep. 2011 were divided into three groups and retrospectively analyzed. Infants in the control group received conventional therapy. Infants in erythromycin group were administered orally with low- dose erythromyein in addition to the conventional therapy. Infants in the amino acid formula group were administered with low-dose erythromycin and amino acid based-formula in addition to the conventional therapy. The days taken for feeding intolerance symptoms disappearance, ideal weight gain and parenteral nutrition were compared among three groups. Results Compared with the control group, the days of symptoms disappearance, ideal weight gain, parenteral nutrition and achieving full enteral feeding were shorter in erythromycin group and shortest in amino acid formula group （P〈0.01）. Conclusions The combined treatment of low-dose erythromycin and amino acid based-formula can promote feeding tolerance in premature infants.