期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

联合地塞米松治疗与肺炎链球菌脑膜炎室管膜下区碱性成纤维细胞生长因子表达的关系 被引量：2

The relationship between dexamethasone and the expression of basic fibroblast growth factor in subventricular zone of experimental streptococcus pneumoniae meningitis
下载PDF
导出
摘要 目的探讨联合地塞米松(DEX)治疗与肺炎链球菌脑膜炎脑生发区域-室管膜下区(SVZ)碱性成纤维细胞生长因子(bFGF)表达的关系。方法 40只3周龄大鼠建立肺炎链球菌脑膜炎模型,分为抗生素组、抗生素联合DEX组、感染对照组、正常对照组,每组10只。免疫组化检测脑组织bFGF的表达。结果抗生素组大鼠SVZ中的bFGF表达与感染对照组差异无统计学意义(P>0.05),而使用抗生素联合DEX组大鼠bFGF表达高于抗生素治疗组及感染对照组,差异均有统计学意义(P<0.01)。结论在肺炎链球菌脑膜炎病程中,联合DEX治疗可以上调bFGF在SVZ中的表达,可能有利于其促进神经生发,有利于抵御细菌性脑膜炎脑损伤。 Objective To investigate the relationship between dexamethasone （DEX） and the expression of basic fibroblast growth factor （bFGF） in subventricular zone （SVZ） of experimental streptococcus pneumoniae meningitis. Methods Forty 3-week- old rats were used to develop the model of streptococcus pneumoniae meningitis, and were randomly divided into 4 groups of 10 rats each, antibiotic group, antibiotic plus DEX group, infection control group and normal control group. The expression level ofbFGF in SVZ was detected by immunohistochemical staining. Results The expression level ofbFGF in SVZ of rats in antibiotic group was similar to that of rats in infection control group （P〉0.05）. However, the expression level ofbFGF in SVZ of rats in antibiotic plus DEX group was significantly higher than that of rats in antibiotic group and infection control group （P〈0.01）. Conclusions In the course of streptococcus pneumoniae meningitis, the combination therapy of antibiotics and DEX can up-regulate the expression level of bFGF in SVZ, which may promote neurogenesis and protect against brain injury in bacterial meningitis.
作者 赵秀英 李玲 廖锋 向伟
机构地区 海南省人民医院儿科 上海交通大学医学院附属新华医院儿内科 海南省妇幼保健院
出处 《临床儿科杂志》 CAS CSCD 北大核心 2013年第4期351-354,共4页 Journal of Clinical Pediatrics
基金 国家自然科学基金资助项目(No.81171630)
关键词 地塞米松 碱性成纤维细胞生长因子 室管膜下区 脑膜炎 dexamethasone basic fibroblast growth factor subventricular zone meningitis
分类号 R725.1 [医药卫生—儿科]
  • 相关文献

参考文献16

  • 1Zhang RL, Zhang ZG, Chopp M. Ischemic stroke and neuro- genesis in the subventricular zone [J]. Neuropharmacology, 2008, 55(3): 345-352.
  • 2Brazel CY, Bunanko MJ Bothstein RP, et aL Roles of the mammalian subventricular zone in brain development [J]. Prog Neurobiol, 2003, 69(1): 49-69.
  • 3Agasse F, Benzakour O, Berjeaud JM, et al. Endogenous fac- tors derived from embryonic cortex regulate proliferation and neuronal differentiation of postnatal subventricular zone cell cultures [J]. EurJ Neurosci, 2006, 23(8): 1970-1976.
  • 4Baldauf K, Reymann KG. Influence of EGF/bFGF treatment on proliferation, early neurogenesis and infarct volume after tran- sient focal ischemia [J]. Brain Res, 2005, 1056(2); 158-167.
  • 5Jin-qiao S, Bin S, Wen-hao Z, et al. Basic fibroblast growth factor stimulate the proliferation and differentiation of neural stem cell in neonatal rats after ischemic brain injury [J]. Brain Dev, 2009, 31(5): 331-340.
  • 6Jungnickel J, HaaseK, Konitzer J, et al. Faster nerve regen- eration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor [J]. Neurobiol, 2006, 66(9): 940-948.
  • 7Fauci AS. Infections disease.. Considerations for the 21th cen- tury [J]. Clin inteet Dis, 2001, 32(5): 675-685.
  • 8Yagita Y, Kitagava K, Sasaki T, et al. Differential expression of Musashil and nestin in the adult rat hippocampus after is- chemia [J]. Neurosci Res, 2002, 69(6): 750-756.
  • 9Sun D, Bullock MR, McGinn M J, et al. Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury [J]. Exp Neurol, 2009, 216(1):56-65.
  • 10Gritti A, Bonfanti L, Doetsch F, et al. Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents [J]. Neurosci, 2002, 22(2): 437-445.

二级参考文献14

  • 1Zhang RL,Zhang ZG,Chopp M. Ischemic stroke and neurogenesis in the subventricular zone [ J ]. Neuropharmacology ,2008 ,55 ( 3 ) :345 - 352.
  • 2Pluchino S, Muzio L, lmitola J, et al. Persistent inflammation ahers the function of the endogenous brain stem cell compartment [ J ]. Brain, 2008 [ Epub ahead of print ].
  • 3Iosif RE, Ahlenius H, Ekdahl CT,et al. Suppression of stroke -induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1 [ J ]. J Cereb Blood Flow Metab , 2008,28 ( 9 ) : 1574 - 1587.
  • 4Salazar- Colocho P,Lanciego JL, Del Rio J. Ischemia induces cell pro- liferation and neurogenesis in the gerbil hippocampus in response to neu- ronal deathαNeurosci Res,2008,61 ( 1 ) :27 -37.
  • 5Agasse F, Benzakour O, Berjeaud JM, et al. Endogenous factors derived from embryonic cortex regulate proliferation and neuronal differentiation of postnatal subventricular zone cell cultures [ J ]. Eur J Neurosci,2006, 23(8) :1970 - 1976.
  • 6Baldauf K, Reymann KG. Influence of EGF/bFGF treatment on proliferation, early neurogenesis and infarct volume after transient focal ischemia [ J ]. Brain Res,2005,1056 (2) : 158 - 167.
  • 7Fauci AS. Infectious disease : Conside rations for the 21 st century [ J ]. Clin Infect D/s,2001,32 ( 5 ) : 675 - 685.
  • 8Jin - Qiao S,Bin S,Wen - Hao Z,et al. Basic fibroblast growth factor stimulates the proliferation and differentiation of neural stem cells in neonatal rats after ischemic brain injury [ J ]. Brain Dev, 2008 [ Epub a- head of print ].
  • 9Kiprianova I, Schindowski K, yon Bohlen, et al. Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF -2[J]. Exp Neurol,2004,189(2) :252 -260.
  • 10Agasse F,Nicoleau C,Petit J,et al. Evidence for a major role of endogenous fibroblast growth factor - 2 in apoptotic cortex - induced subventricular zone cell proliferatlori [ J ]. Eur J Neurosci, 2007,26 ( 11 ) : 3036 - 3042.

共引文献2

同被引文献38

  • 1刘心洁,孙若鹏,雷革非,李保敏,李颖.大鼠肺炎链球菌脑膜炎病理机制及干预措施的初步研究[J].中华儿科杂志,2005,43(4):294-296. 被引量：7
  • 2HASELOFF R F, DITHMER S, WINKLER L, et al. Transmem- brane proteins of the tight junctions at the blood - brain barrier: structural and functional aspects[ J]. Semin Cell Dev Biol, 2014, 38:16-25.
  • 3OBERMEIER B, DANEMAN R, RANSOHOFF R M. Develop- ment, maintenance and disruption of the blood- brain barrier[ J]. Nat Med, 2013, 19(12): 1584-1596.
  • 4CAI J, PAN R, JIA X, et al. The combination of astragalus mem- branaceus and ligustrazine ameliorates micro - haemorrhage by maintaining blood - brain barrier in egrity in cerebrally ischaemic rats[J]. J Ethnopharmacol, 2014, 158 Pt A: 301 -309.
  • 5DU K X, DONG Y, ZHANG Y, et al. Effects of daxamethasone on aquaporin - 4 expression in brain tissue of rat with bacterial meningitis[ J]. Int J Clin Exp Pathol, 2015, 8(3) : 3090 -3096.
  • 6BODILSEN J, DALAGER PEDERSEN M, SCHONHEYDER H C, et al. Dexamethasone treatment and prognostic factors in com- munity - acquired bacterial meningitis : a Danish retrospective pop- ulation - based cohort study [ J ]. Scand J Infect Dis, 2014, 46 (6) : 418 -425.
  • 7HECKENBERG S G, BROUWER M C, VAN DE BEEK D. Bac- terial meningitis [ J]. Handb Clin Neurol, 2014, 121:1361 - 1375.
  • 8CUTI?ING A S, DEL ROSARIO Y, MU R, et al. The role of auto- phagy during group B Streptococcus infection of blood - brain bar- rierendothelium[J]. J Biol Chem, 2014, 289(52): 35711 - 35723.
  • 9WANG Z, XUE Y, JIAO H, et al. Doxycycline - mediated pro- tective effect against focal cerebral ischemia - reperfusion injury through the modulation of tight junctions and PKδ signaling in rats[J]. J Mol Neurosci, 2012, 47(1) : 89 -100.
  • 10VAN ITALLIE C M, ANDERSON J M. Claudin interactions in and out of the tight junction [ J ]. Tissue Barriers, 2013, 1 (3) : e25247.

引证文献2

二级引证文献5

临床儿科杂志
2013年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部