淋巴瘤样丘疹病17例临床分析

Clincal Analysis on 17 Cases of Lymphomatoid Papulosis

目的分析淋巴瘤样丘疹病临床表现、组织病理及免疫组化特征。方法检索2000年1月-2010年12月中国知网和万方数据库中的国家级专业期中报道的淋巴瘤样丘疹病患者的文献资料,并进行分析和总结。结果淋巴瘤样丘疹病有以自限性红斑和口腔溃疡为首发症状的报道,组织病理见表皮角化不全、楔形坏死、水肿或正常,真皮内瘤细胞以楔形分布、团块状或结节状浸润为主,血管炎样表现较为常见。免疫组化染色见异型细胞表达T细胞免疫表型,多数CD3阳性表达,但CD68,CD4,CD45RO和LCA阳性率也比较高,几乎全部见CD30抗原表达。结论淋巴瘤样丘疹病临床表现多样,应加强对此病的认识,做到早诊断、早治疗并定期随访。

Objective To analysis clinical manifestations of lymphomatoid papulosis, organizations pathological and immunohistochemical features. Methods Retrieve the lymphomatoid papulosis patients literature, which reported by the national professional magazine among the CNKI and Wangfang database, from January 2000 to December 2010, then summraring and analyzing. Results The first symptom of lymphomatoid papulosis was self- limting erythema and oral ulcers. Epidermal changing was parekeratosis, the wedge necrosis, edema and normal. The main infiltration distrubtion of tumor cell in dermis was wedge shaped, lumpy and nodular, Vasculitis expressing was the commom performance. Atyptical cell express T cell phenotype, the majority of CD3 cell was positive, the CD68, CD4, CD45RO and LCA cells positive rate were relatively high, almost all cell express CD30 antigen. Conclusion Lymphomatoid Papulosis clinical manifestation is diversity, so we should strengthen the awareness of this disease and must do early dignosis,early treatment, early regular follow-up.