摘要
目的探讨解脲脲原体(UU)及微小脲原体(UP)感染与男性非淋菌性尿道炎(NGU)的关联性。方法采用Meta分析的方法,检索2000-2011年公开发表的有关UU和UP感染与男性NGU的文献,应用Review Manager5.0软件进行综合定量评价,计算其优势比(OR)等。结果共入选9篇中、英文文献,包括1687个病例和1386个对照。脲原体(UU+UP)总体感染率与NGU的关系合并OR值为1.09,95%CI(0.80,1.47),显著性检验P=0.60。UU感染与NGU的关系OR值为1.65,95%CI(1.10,2.47),显著性检验P=0.02,而UP感染与NGU的关系OR值为0.57,95%CI(0.45,0.72),显著性检验P<0.00001。结论 UU主要分布于NGU组中,有较强的致病性,而UP更常见于对照组中,可能以寄居的形式存在。进行UU和UP区分检测对临床诊断和流行病学的调查将有重要意义。
Objective To investigate the correlation between Ureaplasma urealyticum, Ureaplasma parvum infection and male nongonococcal urethritis. Methods The studies on the relationship of ureaplasmas infection and male nongonococcal urethritis were collected by searching from Pubmed database, CBM database, CNKI database and so on(2000- 2011 ), and analyzed by meta-analysis. The odds ratio was calculated by Review Manager 5.0 software. Results Nine studies accorded with research criteria including 1687 cases and 1 386 controls were analyzed. The combined OR value of Ureaplasmas infection to male NGU was 1.09, 95% CI(O. 80,1.47), the test for overall effect P = 0.60. However, the OR value of UU infection to male NGU was 1.65, 95% CI( 1.10,2.47), the test for overall effect P =0.02. But, contrary to UU, the OR value of UP infection to NGU was 0.57, 95% CI(O. 45,0.72), the test for overall effect P 〈0. 000 01. Conclusion UU mainly exists in the NGU group, and has the higher virulence. However, UP is detected more frequently in the control group and may be the parasitic microorganism in the male urethra. So, it is important to detect separately Ureaplasma urealyticum and Ureaplasma parvum. It will have far-reaching influence for clinical diagnosis and epidemiological survey.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2013年第4期380-382,434,共4页
The Chinese Journal of Dermatovenereology