副肿瘤性肢端角化症1例并文献复习

Acrokeratosis Paraneoplastica (Bazex Syndrome) : A Case Report and Literature Review

患者男,38岁。双足背部褐色斑块并上覆灰白色鳞屑半年。皮损组织病理示:角化过度,颗粒层增厚,棘层肥厚,表皮呈乳头瘤样增生。真皮乳头层血管周围少量淋巴细胞浸润,真皮深层及皮下脂肪组织未见异常。随访4年时胃镜检查证实为食管癌。诊断:副肿瘤性肢端角化症。文中并对本病进行相并文献复习。

A 38-years-old male, who had presented with brown plaque and gray scales on double dorsal feet for half a year. The histopathology of the skin lesion showed that epidermis was hyperkeratosis, granular layer, acanthosis, papillomatosis . There were a few lymphoeytes infiltrated around the blood vessels in dermal papilla layer. The deep dermis and subcutaneous fat tissues showed no abnormalities. After 4 years traeking observation, This patient was confirmed with esophageal cancer. Diagnosis was acrokeratosis paraneoplastiea. Moreover, we also reviewed the literature related to bazex syndrome.