氧化应激与表皮通透屏障功能降低性皮肤病

Oxidative Stress and Dermatoses Accompanied by Compromised Epidermal Permeability Barrier Function

很多伴有表皮通透屏障功能降低的皮肤病的发生和发展与氧化应激有关。氧化产物的量与皮肤病的严重程度呈正相关性;表皮通透屏障功能的异常程度与皮肤病的严重程度呈正相关性;抗氧化剂在缓解皮肤病的同时,表皮通透屏障功能也得以改善。而增强表皮通透屏障功能可使这些皮肤病得到缓解。此外,皮肤衰老也与氧化应激有关,老年的皮肤的抗氧化能力和表皮通透屏障功能的恢复能力均降低。外用抗氧化剂具有抗皮肤衰老的作用。由此提示,抗氧化或改善表皮通透屏障功能可能有助于防治与其相关的皮肤病。抗氧化剂可用于延缓皮肤衰老。

The occurrence and development of dermatoses accompanied by compromised epidermal permeability barrier function are closely associated with oxidative stress. Studies have demonstrated that both the content of oxidative products and the extent of epidermal permeability barrier abnormality correlate positively with the severity of those skin disorders. Administrations of antioxidants can improve both skin disorders and epidermal permeability barrier function. Likewise improving epidermal permeability barrier function can alleviate skin dis-orders with defective barrier function. In addition, skin aging is also associated with oxidative stress. Aged skin exhibits lower antioxidant capacity and delayed barrier recovery. Topical antioxidants display anti-aging effects. Therefore, approaches of either administering antioxidants or enhancing epidermal permeability barrier function could be helpful in preventing and treating dermatoses accompanied by defective epidermal permeability barrier function. Antioxidants could be useful in slowing skin aging.