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CSMD1在黑色素瘤A375细胞中的表达及意义 被引量：1

The expression and significance of CSMD1 in melanoma
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摘要 目的研究CSMD1在黑色素瘤A375细胞中的表达情况，探讨CSMD1对A375黑色素瘤细胞的调控作用。方法培养人黑色素瘤A375细胞株（实验组）和正常人皮肤TE353．Sk细胞株（对照组），应用RT-PCR及Western blot技术，检测CSMD1mRNA和蛋白在A375细胞和TE353．Sk细胞中的表达情况，并进行统计学分析。结果与对照组正常人皮肤TE353．Sk细胞株相比，实验组人黑色素瘤A375细胞株中的CSMD1mRNA和蛋白的表达水平较低（P〈0．05）。结论CSMD1可能是黑色素瘤细胞的抑制基因，可能为黑色素瘤的治疗提供一种新的研究方法。 Objective To study the expression of CSMD1 A375 melanoma cell and investigate the regulation of CSMD1 to A375 melanoma cell. Methods A375 melanoma cell and human skin TE 353. Sk cell were cultured as the experimental group and control group. The expression of CSMD1 mRNA and protein in A375 cell and TE 353. SK cell were detected with RT-PCR and western blotting. Results The expression of CSMD1 mRNA and protein in A375 cell was lower than that in TE 353. Sk cell. Conclusion CSMD1 is the inhibition gene to melanoma cell and it can be used as a new method for treating melanoma.
作者 唐明睿 王玉新 郭澍 孙强 王迪
机构地区 中国医科大学附属第一医院整形外科
出处 《中国美容整形外科杂志》 CAS 2013年第4期253-255,共3页 Chinese Journal of Aesthetic and Plastic Surgery
关键词 CSMD1 黑色素瘤 A375细胞 TE353 Sk细胞 CSMD1 Melanoma A375 cell TE 353. Sk cell
分类号 R739.5 [医药卫生—肿瘤]
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参考文献19

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同被引文献9

  • 1Farrell LC,Crimm H,Meeh P,et al.Somatic mutations to CSMD1 in colorectal adenocarcinomas[J].Cancer Biol Ther,2008,7(4):609-613.
  • 2Wright K,Wilson PJ,Kerr J,et al.Frequent loss of heterozygosity and three critical regions on the short arm of chromosome 8 in ovarian adenocarcinomas[J].Oncogene,1998,17(9):1185-1188.
  • 3Kerbel RS.A cancer therapy resistant to resistance[J].Nature,1997,390(6658):335-336.
  • 4Garbe C,Peris K,Hauschild A,et al.Diagnosis and treatment of melanoma.European consensus-based interdisciplinay guideline Update2012[J].Eur J Cancer,2010,48(15):2375-2390.
  • 5Ma C,Quesnelle KM,Sparano A,et al.Characterization CSMD1 in a large set of primary lung,head and neck,breast and skin cancer tissues[J].Cancer Biol Ther,2009,8(10):907-916.
  • 6Henshall SM,Afar DE,Hiller J,et al.Survival analysis of genomewide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse[J].Cancer Res,2003,63(14):196.
  • 7Kamal M,Shaaban AM,Zhang L,et al.Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma[J].Breast Cancer Res Treat,2010,121(3):555-563.
  • 8Midorikawa Y,Yamamoto S,Tsuji S,et al.Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis[J].Hepatology,2009,49(2):513-522.
  • 9王亚丽(综述),吴瑾(审校).恶性黑色素瘤诊断与治疗进展[J].中国综合临床,2012,28(11):1226-1228. 被引量：6

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中国美容整形外科杂志
2013年 第4期

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